Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development (Q28251468)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25389409%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

review article

1 reference

title

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development (English)

1 reference

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22 February 2020

1

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22 February 2020

Francesca Vinchi

2

1 reference

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22 February 2020

Emanuela Tolosano

4

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22 February 2020

author name string

Giada Ingoglia

3

1 reference

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22 February 2020

Paul W Buehler

5

1 reference

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22 February 2020

language of work or name

English

0 references

publication date

28 October 2014

1 reference

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22 February 2020

published in

Frontiers in Physiology

2 references

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22 February 2020

volume

5

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22 February 2020

page(s)

415

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Structure of the haptoglobin-haemoglobin complex

22 February 2020

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Association between haptoglobin, hemopexin and mortality in adults with sepsis

29 September 2017

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Extracellular hemin crisis triggers acute chest syndrome in sickle mice

29 September 2017

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Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

29 September 2017

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Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent

29 September 2017

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29 September 2017

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Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

29 September 2017

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Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin

29 September 2017

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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

29 September 2017

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Identification of hemopexin as an anti-inflammatory factor that inhibits synergy of hemoglobin with HMGB1 in sterile and infectious inflammation

29 September 2017

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Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145

29 September 2017

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Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

29 September 2017

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Haptoglobin activates innate immunity to enhance acute transplant rejection in mice.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Hemoglobin-based oxygen carriers: current status and future directions

29 September 2017

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Heme degradation and vascular injury.

29 September 2017

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Haptoglobin: basic and clinical aspects

29 September 2017

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Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin

29 September 2017

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Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages

29 September 2017

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Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS.

29 September 2017

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Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin

29 September 2017

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29 September 2017

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29 September 2017

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The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

29 September 2017

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No scavenging and the hypertensive effect of hemoglobin-based blood substitutes

29 September 2017

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Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease

29 September 2017

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Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

29 September 2017

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Identification of the haemoglobin scavenger receptor.

29 September 2017

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Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli

29 September 2017

1 reference

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Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family

29 September 2017

1 reference

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Presence of hemoglobin inside aortic endothelial cells after cell-free hemoglobin administration in guinea pigs.

29 September 2017

1 reference

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Tetramer-dimer equilibrium of oxyhemoglobin mutants determined from auto-oxidation rates

29 September 2017

1 reference

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Biological and clinical significance of haptoglobin polymorphism in humans

29 September 2017

1 reference

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Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage

29 September 2017

1 reference

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Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis

29 September 2017

1 reference

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The renal handling of hemoglobin. I. Glomerular filtration

29 September 2017

1 reference

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The linkage between oxygenation and subunit dissociation in human hemoglobin

29 September 2017

1 reference

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Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211382

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211382

Red cells, hemoglobin, heme, iron, and atherogenesis

2 June 2018

1 reference

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Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin.

2 June 2018

1 reference

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Hemopexin: a unique genetic polymorphism in populations of African ancestry

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211382

Exchange of heme among hemoglobins and between hemoglobin and albumin

2 June 2018

1 reference

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On the use of concentrated haptoglobin in the treatment of a haemolytic transfusion accident of the ABO-system (author's transl)

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211382

Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo

2 June 2018

1 reference

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Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.

21 January 2018

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Fast determination of haptoglobin phenotype and calculation of hemoglobin binding capacity using high pressure gel permeation chromatography.

21 January 2018

1 reference

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Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption.

21 January 2018

1 reference

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Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163.

21 January 2018

1 reference

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Characterization of heme as activator of Toll-like receptor 4.

21 January 2018

1 reference

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Haptoglobin deficiency facilitates the development of autoimmune inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Identification of the receptor scavenging hemopexin-heme complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Pro-oxidant and cytotoxic effects of circulating heme.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Influence of clinical factors on the haemolysis marker haptoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Appearance of dissociable and cross-linked hemoglobins in the renal hilar lymph.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Pivotal advance: activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163*

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2014.00415

Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211382

Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211382

Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma

27 November 2018

1 reference

12 December 2020

Hemoglobin-based oxygen carriers: current status and future directions

1 reference

12 December 2020

Pharmacological intervention for renal protection during cardiopulmonary bypass

1 reference

12 December 2020

Administration of haptoglobin during cardiopulmonary bypass surgery

1 reference

12 December 2020

Repeated large-dose haptoglobin therapy in an extensively burned patient: case report

1 reference

12 December 2020

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

1 reference

12 December 2020

Increased Expression of Oxidation-Specific Epitopes and Apoptosis Are Associated With Haptoglobin Genotype

1 reference

12 December 2020

A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process.

1 reference

12 December 2020

Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression

1 reference

12 December 2020

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

1 reference

12 December 2020

Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin

1 reference

12 December 2020

Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids.

1 reference

12 December 2020

Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion

1 reference

12 December 2020

The role of haptoglobin in the clearance and distribution of extracorpuscular hemoglobin

1 reference

12 December 2020

Mechanisms of plasma hemoglobin clearance after acute hemolysis in dogs: serum haptoglobin levels and selective deposition in liver and kidney

1 reference

12 December 2020

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury

1 reference

12 December 2020

Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig

1 reference

12 December 2020

Permeability characteristics of hemoglobin derivatives across cultured endothelial cell monolayers

1 reference

12 December 2020

Stability of the heme-globin linkage in alphabeta dimers and isolated chains of human hemoglobin. A study of the heme transfer reaction from the immobilized proteins to albumin

1 reference

12 December 2020

Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression

1 reference

12 December 2020

Transgenic sickle mice have vascular inflammation

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHYS.2014.00415

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25389409%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25389409%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25389409%20AND%20SRC:MED&resulttype=core&format=json