Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene (Q28253085)

Annals of the New York Academy of Sciences

Europe PubMed Central

title

Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene (English)

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author name string

He Li

series ordinal

1

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Jun-Ping Liu

series ordinal

2

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language of work or name

English

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publication date

October 2007

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published in

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volume

1114

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page(s)

56-68

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cites work

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

Multiple tumor suppressor pathways negatively regulate telomerase

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

Smad transcription factors

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

Smads bind directly to the Jun family of AP-1 transcription factors

21 April 2017

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1396.016

A survey of telomerase activity in human cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Switching and signaling at the telomere

21 April 2017

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

21 April 2017

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

TGF-beta signaling: positive and negative effects on tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Signaling through the Smad pathway by insulin-like growth factor-binding protein-3 in breast cancer cells. Relationship to transforming growth factor-beta 1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Smad3 mutant mice develop metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Telomerase in the human organism

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Telomerase is not an oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Telomeres and telomerase: their mechanisms of action and the effects of altering their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Mechanism for the reduction of telomerase expression during muscle cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Transcriptional regulation and transformation by Myc proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Direct activation of TERT transcription by c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

TGF-beta and cancer: is Smad3 a repressor of hTERT gene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Cyclin-dependent kinases regulate the antiproliferative function of Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1196%2FANNALS.1396.016