Promoter methylation and loss of p16(INK4a) gene expression in head and neck cancer (Q28253632)

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Alice Chuang

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Yusufhan Suoğlu

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Murat Ulusan

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Zubeyde Yalnız

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Nejat Dalay

Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control

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language of work or name

English

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publication date

October 2012

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34

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issue

10

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page(s)

1470-5

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cites work

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DNA methylation and cancer

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Role of DNA methylation in head and neck cancer

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p16INK4a and p14ARF methylation as a potential biomarker for human bladder cancer.

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Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.

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DNA hypermethylation status of multiple genes in soft tissue sarcomas

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Expression and methylation pattern of p16 in neuroblastoma tumorigenesis

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Frequent p16 inactivation by homozygous deletion or methylation is associated with a poor prognosis in Japanese patients with pleural mesothelioma.

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Pediatric histiocytic sarcoma clonally related to precursor B-cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4A.

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CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survival

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Clinicopathological roles of alterations of tumor suppressor gene p16 in papillary thyroid carcinoma.

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Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications

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Identification of genes differentially expressed in human primary lung squamous cell carcinoma

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The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance

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Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma

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CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma.

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p16INK4a hypermethylation and p53, p16 and MDM2 protein expression in esophageal squamous cell carcinoma

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Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area.

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Hypermethylation of p16 gene promoter correlates with loss of p16 expression that results in poorer prognosis in esophageal squamous cell carcinomas

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Specific 50'CpG island methylation signatures of FHIT and p16 genes and their potential diagnostic relevance in Indian breast cancer patients

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Promoter Hypermethylation in Tumor Suppressing Genes p16 and FHIT and Their Relationship with Estrogen Receptor and Progesterone Receptor Status in Breast Cancer Patients from Northern India

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p16 methylation does not affect protein expression in cervical carcinogenesis

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Promoter methylation of p16, DAPK, CDH1, and TIMP-3 genes in cervical cancer: correlation with clinicopathologic characteristics.

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The p16 (CDKN2a/INK4a) tumor-suppressor gene in head and neck squamous cell carcinoma: a promoter methylation and protein expression study in 100 cases

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Aberrant promoter methylation of p16 in colorectal adenocarcinoma in North Indian patients

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Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Promoter hypermethylation in Indian primary oral squamous cell carcinoma.

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Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma

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Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma

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p16(MTS-1/CDKN2/INK4a) in cancer progression

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Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma.

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The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression

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Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas.

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Histopathologic findings of HPV and p16 positive HNSCC

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Detection of HPV and the role of p16INK4A overexpression as a surrogate marker for the presence of functional HPV oncoprotein E7 in colorectal cancer

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Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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The fundamental role of epigenetic events in cancer

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7 January 2021

Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population

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7 January 2021

Germ-line mutations of the p16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma

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p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma

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P16 alterations increase the metastatic potential of endometrial carcinoma

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Promoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma

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Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue

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Aberrant p16((INK4a)) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity

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Assessment of microsatellite instability in head and neck cancer using consensus markers

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Simultaneous methylation profiling of tumor suppressor genes in head and neck cancer

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Association of K-ras mutations with p16 methylation in human colon cancer

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Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population

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Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma

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p16 gene methylation in colorectal cancers associated with Duke's staging

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7 January 2021

Hypermethylation of the p16/CDKN2A/MTSI gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas

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Association Between Hypermethylated Tumor and Paired Surgical Margins in Head and Neck Squamous Cell Carcinomas

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7 January 2021