A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling (Q28253982)

3

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author name string

L Hamann

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A Visintin

4

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J Eckert

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P M Schlag

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R R Schumann

Toll-like receptors: critical proteins linking innate and acquired immunity

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language of work or name

English

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publication date

June 2004

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published in

Genes and Immunity

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volume

5

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issue

4

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page(s)

283-8

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cites work

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

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Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4

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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

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Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

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Cytokine and cytokine receptor polymorphisms in infectious disease

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Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction

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Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product

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Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders

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A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

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The role of disulfide bonds in the assembly and function of MD-2

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Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis

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Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction

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Toll-like Receptor 4 Polymorphisms and Atherogenesis

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Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease.

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Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein

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