MAFG is a transcriptional repressor of bile acid synthesis and metabolism (Q28256483)

1

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Elizabeth J Tarling

2

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Hannah Ahn

3

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Lee R Hagey

4

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Casey E Romanoski

5

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Richard G Lee

6

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Mark J Graham

7

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Hozumi Motohashi

8

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Masayuki Yamamoto

9

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Peter A Edwards

Nuclear Receptors, RXR, and the Big Bang

10

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language of work or name

English

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publication date

3 February 2015

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published in

Cell Metabolism

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volume

21

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issue

2

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page(s)

298-310

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cites work

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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

20 March 2017

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20 March 2017

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Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene

20 March 2017

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Structural Basis of Alternative DNA Recognition by Maf Transcription Factors

20 March 2017

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

20 March 2017

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Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

20 March 2017

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

20 March 2017

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Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes

20 March 2017

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Nrf2 transcriptionally activates the mafG gene through an antioxidant response element

20 March 2017

1 reference

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The enzymes, regulation, and genetics of bile acid synthesis

20 March 2017

1 reference

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

20 March 2017

1 reference

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Bile acids: natural ligands for an orphan nuclear receptor

20 March 2017

1 reference

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Identification of a nuclear receptor for bile acids

20 March 2017

1 reference

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Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice

20 March 2017

1 reference

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Gut microbiota from twins discordant for obesity modulate metabolism in mice

20 March 2017

1 reference

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Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

7 April 2017

1 reference

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

7 April 2017

1 reference

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

7 April 2017

1 reference

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Beyond intestinal soap--bile acids in metabolic control.

7 April 2017

1 reference

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Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

29 September 2017

1 reference

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Pleiotropic roles of bile acids in metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor

29 September 2017

1 reference

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Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.

29 September 2017

1 reference

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Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

29 September 2017

1 reference

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Identification of a chemical tool for the orphan nuclear receptor FXR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Redundant pathways for negative feedback regulation of bile acid production

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317590

The feedback control of cholestrol biosynthesis

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25651182

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2015.01.007

1 reference

1 reference

1 reference

PubMed publication ID

25651182

1 reference