Mechanism of homologous recombination: mediators and helicases take on regulatory functions (Q28259452)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Mechanism of homologous recombination: mediators and helicases take on regulatory functions (English)

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author name string

Patrick Sung

series ordinal

1

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Hannah Klein

series ordinal

2

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language of work or name

English

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publication date

October 2006

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published in

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volume

7

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issue

10

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page(s)

739-50

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cites work

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A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae

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Crystal structure of a Rad51 filament

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Human Dmc1 protein binds DNA as an octameric ring.

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Recombination activities of HsDmc1 protein, the meiotic human homolog of RecA protein

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Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

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Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52.

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DNA strand annealing is promoted by the yeast Rad52 protein

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Interaction with Rad51 is indispensable for recombination mediator function of Rad52.

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DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA

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Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells

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Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52.

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Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

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Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

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Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57.

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Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes

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Identification and purification of two distinct complexes containing the five RAD51 paralogs

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Evidence for simultaneous protein interactions between human Rad51 paralogs

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Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

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Interplay between human DNA repair proteins at a unique double-strand break in vivo

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Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange

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RAD51C is required for Holliday junction processing in mammalian cells

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

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Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

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BRCA2 is required for homology-directed repair of chromosomal breaks

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RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

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RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis.

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Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

31 March 2020

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The Bloom's syndrome gene product is homologous to RecQ helicases

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The Bloom's syndrome gene product is a 3'-5' DNA helicase

31 March 2020

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A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

31 March 2020

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The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.

31 March 2020

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Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates

31 March 2020

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RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene

31 March 2020

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Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins

31 March 2020

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Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase.

31 March 2020

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

31 March 2020

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Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein

31 March 2020

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

31 March 2020

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Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

31 March 2020

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

31 March 2020

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Molecular dissection of mitotic recombination in the yeast Saccharomyces cerevisiae

31 March 2020

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Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase

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Happy Hollidays: 40th anniversary of the Holliday junction

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31 March 2020

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BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

31 March 2020

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A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.

31 March 2020

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The Sgs1 Helicase Regulates Chromosome Synapsis and Meiotic Crossing Over

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Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.

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Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing

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The Saccharomyces cerevisiae MER3 gene, encoding a novel helicase-like protein, is required for crossover control in meiosis

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The MER3 DNA helicase catalyzes the unwinding of holliday junctions

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Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51; implications for crossover control in meiotic recombination

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Direct DNA binding by Brca1

31 March 2020

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

31 March 2020

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Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression

31 March 2020

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M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex

31 March 2020

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Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

31 March 2020

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Biallelic inactivation of BRCA2 in Fanconi anemia

31 March 2020

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DNA polymerase V and RecA protein, a minimal mutasome.

31 March 2020

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Mechanism and regulation of human non-homologous DNA end-joining

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Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis

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Meiotic recombination: an affair of two recombinases.

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Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation

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The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination.

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Mutants of Yeast Sensitive to Ultraviolet Light

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inferred from DOI database lookup

7 January 2021

based on heuristic

Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM2008

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

224419

1000968951

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Fatcat ID

release_477xbsha7rbopo3f5fnvmcyuyi

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https://api.fatcat.wiki/v0/release/477xbsha7rbopo3f5fnvmcyuyi

mapped directly with Wikidata item

24 November 2022

based on heuristic

224419

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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