RecQ helicases: caretakers of the genome (Q29618390)

Europe PubMed Central

title

RecQ helicases: caretakers of the genome (English)

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30 April 2017

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1

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30 April 2017

language of work or name

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30 April 2017

publication date

March 2003

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30 April 2017

published in

Nature Reviews Cancer

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30 April 2017

volume

3

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issue

3

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30 April 2017

page(s)

169-78

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612652

Unwinding the 'Gordian knot' of helicase action.

30 April 2017

cites work

1 reference

RecQ family helicases: roles in cancer and aging

21 January 2018

1 reference

DNA helicases, genomic instability, and human genetic disease

21 January 2018

1 reference

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

21 January 2018

1 reference

Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway.

21 January 2018

1 reference

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

21 January 2018

1 reference

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

21 January 2018

1 reference

BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal

21 January 2018

1 reference

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

21 January 2018

1 reference

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

21 January 2018

1 reference

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

21 January 2018

1 reference

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta

21 January 2018

1 reference

The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

1 reference

Positional cloning of the Werner's syndrome gene

21 January 2018

1 reference

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

21 January 2018

1 reference

The Werner syndrome protein: an update

21 January 2018

1 reference

The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases

21 January 2018

1 reference

Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients

21 January 2018

1 reference

WRN mutations in Werner syndrome

21 January 2018

1 reference

Genetic instabilities in human cancers

21 January 2018

1 reference

Caretaker tumour suppressor genes that defend genome integrity

21 January 2018

1 reference

Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype

21 January 2018

1 reference

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes

21 January 2018

1 reference

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

21 January 2018

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Loss of Werner syndrome protein function promotes aberrant mitotic recombination

21 January 2018

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Homologous recombination resolution defect in werner syndrome

21 January 2018

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Mutator phenotype of Werner syndrome is characterized by extensive deletions

21 January 2018

1 reference

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

21 January 2018

1 reference

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

21 January 2018

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A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

21 January 2018

1 reference

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

21 January 2018

1 reference

The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs

21 January 2018

1 reference

Substrate-specific inhibition of RecQ helicase

21 January 2018

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G-quadruplex DNA: a potential target for anti-cancer drug design

21 January 2018

1 reference

The Bloom's syndrome gene product promotes branch migration of holliday junctions

21 January 2018

1 reference

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 January 2018

1 reference

Processing of recombination intermediates by the RuvABC proteins

21 January 2018

1 reference

Nuclear structure in normal and Bloom syndrome cells

21 January 2018

1 reference

BLM, the Bloom's syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins

21 January 2018

1 reference

A role for PML and the nuclear body in genomic stability

21 January 2018

1 reference

Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies.

21 January 2018

1 reference

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

21 January 2018

1 reference

Regulation and localization of the Bloom syndrome protein in response to DNA damage

21 January 2018

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Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1

21 January 2018

1 reference

Werner helicase is localized to transcriptionally active nucleoli of cycling cells

21 January 2018

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Nucleolar localization of the Werner syndrome protein in human cells

21 January 2018

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Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

21 January 2018

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p53-mediated apoptosis is attenuated in Werner syndrome cells

21 January 2018

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Physical and functional interaction between p53 and the Werner's syndrome protein

21 January 2018

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Functional interaction of p53 and BLM DNA helicase in apoptosis

21 January 2018

1 reference

p53 Modulates the exonuclease activity of Werner syndrome protein

21 January 2018

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The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

21 January 2018

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Functional and physical interaction between WRN helicase and human replication protein A

21 January 2018

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Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

21 January 2018

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Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

21 January 2018

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Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

21 January 2018

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The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

21 January 2018

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RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination

21 January 2018

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The Bloom's syndrome gene product interacts with topoisomerase III

21 January 2018

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The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

1 reference

ATM: a mediator of multiple responses to genotoxic stress

21 January 2018

1 reference

Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

21 January 2018

1 reference

The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair

21 January 2018

1 reference

Mammalian DNA mismatch repair

21 January 2018

1 reference

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

21 January 2018

1 reference

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

1 reference

Biochemical characterization of the WRN-FEN-1 functional interaction

21 January 2018

1 reference

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

21 January 2018

1 reference

DNA repair mechanisms for the recognition and removal of damaged DNA bases.

21 January 2018

1 reference

Functional interaction between Ku and the werner syndrome protein in DNA end processing

21 January 2018

1 reference

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

21 January 2018

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Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

21 January 2018

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Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein

21 January 2018

1 reference

Recombinational DNA repair of damaged replication forks in Escherichia coli: questions

21 January 2018

1 reference

The importance of repairing stalled replication forks

21 January 2018

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Initiation of genetic recombination and recombination-dependent replication

21 January 2018

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Positive torsional strain causes the formation of a four-way junction at replication forks

21 January 2018

1 reference

Rescue of stalled replication forks by RecG: simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation

21 January 2018

1 reference

RecQ helicases and topoisomerases: components of a conserved complex for the regulation of genetic recombination

21 January 2018

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

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Human telomerase and its regulation

21 January 2018

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The telomerase reverse transcriptase: components and regulation

21 January 2018

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Telomeres and their control

21 January 2018

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Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

21 January 2018

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

21 January 2018

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 January 2018

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Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.

21 January 2018

1 reference

Defending genome integrity during DNA replication: a proposed role for RecQ family helicases

21 January 2018

1 reference

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

31 March 2020

1 reference

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

31 March 2020

1 reference

31 March 2020

1 reference

Rothmund-Thomson syndrome.

31 March 2020

1 reference

A rapid method for detecting the predominant Ashkenazi Jewish mutation in the Bloom's syndrome gene

31 March 2020

1 reference

BLM heterozygosity and the risk of colorectal cancer

31 March 2020

1 reference

Enhanced tumor formation in mice heterozygous for Blm mutation

31 March 2020

1 reference

DNA Repair-responses to DNA damage and other aspects of genomic stability. A new journal format

31 March 2020

1 reference

The Bloom's syndrome helicase unwinds G4 DNA

31 March 2020

1 reference

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

31 March 2020

1 reference

DNA repair: The Nijmegen breakage syndrome protein

31 March 2020

1 reference

Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence

31 March 2020

1 reference

SGS1 is required for telomere elongation in the absence of telomerase

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612652

31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1278919

1006173489

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1278919

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12612652

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017