Targeting the sarcomere to correct muscle function (Q28260629)

Nature Reviews Drug Discovery

Europe PubMed Central

title

Targeting the sarcomere to correct muscle function (English)

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author name string

Peter M Hwang

series ordinal

1

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Brian D Sykes

series ordinal

2

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language of work or name

English

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publication date

May 2015

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published in

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volume

14

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page(s)

313-28

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issue

5

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The cardiotonic effects of levosimendan in guinea pig hearts are modulated by beta-adrenergic stimulation.

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Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly

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The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure

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Different effect of the Ca(2+) sensitizers EMD 57033 and CGP 48506 on cross-bridge cycling in human myocardium

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CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction

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Phosphodiesterase inhibitors.

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The interface between MyBP-C and myosin: site-directed mutagenesis of the CX myosin-binding domain of MyBP-C

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Potent stimulation of myofilament force and adenosine triphosphatase activity of canine cardiac muscle through a direct enhancement of troponin C Ca++ binding by MCI-154, a novel cardiotonic agent

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Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

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Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study.

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The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi.

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Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head

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Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts

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Phosphodiesterase III inhibitors for heart failure

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