VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond (Q28260984)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22378343%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond (English)

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24 January 2020

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1

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24 January 2020

Serena Zacchigna

series ordinal

2

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24 January 2020

author name string

M Giacca

series ordinal

1

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S Zacchigna

series ordinal

2

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language of work or name

English

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publication date

1 March 2012

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24 January 2020

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24 January 2020

volume

19

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issue

6

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page(s)

622-629

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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

24 January 2020

cites work

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Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

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Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia

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Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease

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Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia

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Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease

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One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients

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Long-term (2-year) clinical events following transthoracic intramyocardial gene transfer of VEGF-2 in no-option patients.

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Effects of intramyocardial injection of phVEGF-A165 as sole therapy in patients with refractory coronary artery disease--12-month follow-up: angiogenic gene therapy.

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Organization of myocardial activation during ventricular fibrillation after myocardial infarction: evidence for sustained high-frequency sources.

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Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial

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VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial

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Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease.

21 January 2018

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Intramyocardial plasmid-encoding human vascular endothelial growth factor A165/basic fibroblast growth factor therapy using percutaneous transcatheter approach in patients with refractory coronary artery disease (VIF-CAD).

21 January 2018

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Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial.

21 January 2018

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Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

21 January 2018

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Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.

21 January 2018

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Tau associates with actin in differentiating PC12 cells.

21 January 2018

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Inducible adeno-associated virus vectors promote functional angiogenesis in adult organisms via regulated vascular endothelial growth factor expression.

21 January 2018

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Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia

21 January 2018

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Adenovirus-mediated gene transfer of VEGF(121) improves lower-extremity endothelial function and flow reserve

21 January 2018

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Phase I study of direct administration of a replication deficient adenovirus vector containing the vascular endothelial growth factor cDNA (CI-1023) to patients with claudication

21 January 2018

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Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermitt

21 January 2018

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Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease

21 January 2018

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Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment

21 January 2018

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A randomized, double-blind, placebo-controlled, multicenter, pilot study of the safety and feasibility of catheter-based intramyocardial injection of AdVEGF121 in patients with refractory advanced coronary artery disease.

21 January 2018

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A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial

21 January 2018

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Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study

21 January 2018

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Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia

21 January 2018

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Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer

21 January 2018

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Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart.

21 January 2018

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21 January 2018

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21 January 2018

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Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

21 January 2018

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Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors.

21 January 2018

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Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.

21 January 2018

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VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

21 January 2018

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Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

21 January 2018

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Placenta growth factor activates monocytes and correlates with sickle cell disease severity

21 January 2018

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

21 January 2018

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Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.

21 January 2018

1 reference

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Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Neurovascular signalling defects in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial

21 January 2018

1 reference

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VEGF at the neurovascular interface: therapeutic implications for motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Expression of vascular endothelial growth factor receptors in smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

VEGF overexpression via adeno-associated virus gene transfer promotes skeletal muscle regeneration and enhances muscle function in mdx mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Retinoic acid and VEGF delay smooth muscle relative to endothelial differentiation to coordinate inner and outer coronary vessel wall morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Adeno-associated virus-mediated transduction of VEGF165 improves cardiac tissue viability and functional recovery after permanent coronary occlusion in conscious dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

VEGF attenuates development from cardiac hypertrophy to heart failure after aortic stenosis through mitochondrial mediated apoptosis and cardiomyocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Adverse effects of anticancer agents that target the VEGF pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

Induction of angiogenesis in a mouse model using engineered transcription factors

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FGT.2012.17

21 January 2018

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Regulation of vascular endothelial growth factor in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.17

7 January 2021

Identifiers

DOI

10.1038/GT.2012.17

2 references

Consolidated OpenCitations Corpus – April 2017

448547

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22378343%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

448547

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

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