Caspase inhibitors: viral, cellular and chemical (Q28261303)

Cell Death & Differentiation

Europe PubMed Central

title

Caspase inhibitors: viral, cellular and chemical (English)

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author name string

B A Callus

series ordinal

1

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D L Vaux

series ordinal

2

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language of work or name

English

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publication date

January 2007

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published in

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volume

14

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page(s)

73-8

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issue

1

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cites work

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Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo

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Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease

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CATERPILLER: a novel gene family important in immunity, cell death, and diseases

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IAPs, RINGs and ubiquitylation

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Characterization of XIAP-deficient mice

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The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

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The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.

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IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms

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Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth

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Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer

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Functional dissection of an innate immune response by a genome-wide RNAi screen

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Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

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Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

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Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties

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First-in-class pan caspase inhibitor developed for the treatment of liver disease

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7 January 2021

Caspase inhibitors: a pharmaceutical industry perspective

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Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

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7 January 2021

A common allosteric site and mechanism in caspases

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Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species

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First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes.

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Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

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