p21-Activated kinase inhibitors: a patent review (Q28261519)

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The emerging importance of group II PAKs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1).

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Pak protein kinases and their role in cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Activated PAK4 regulates cell adhesion and anchorage-independent growth

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

p21-activated kinase 1: PAK'ed with potential

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Colorectal cancer: mutations in a signalling pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

PAK1 hyperactivation is sufficient for mammary gland tumor formation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

An emerging role for p21-activated kinases (Paks) in viral infections

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Role of the p21-activated kinases (PAKs) in influenza A virus replication

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Human host factors required for influenza virus replication

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

A key role for Pak4 in proliferation and differentiation of neural progenitor cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

PAK signalling in neuronal physiology

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

PAK3 mutation in nonsyndromic X-linked mental retardation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.668758

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The discovery of the potent aurora inhibitor MK-0457 (VX-680).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The influence of the 'organizational factor' on compound quality in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

The methylation effect in medicinal chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

From conventional to unusual enzyme inhibitor scaffolds: the quest for target specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Selectivity of kinase inhibitor fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.668758