Regulation of DNA double-strand break repair pathway choice (Q28262730)

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization

Europe PubMed Central

title

Regulation of DNA double-strand break repair pathway choice (English)

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author name string

Meena Shrivastav

series ordinal

1

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Leyma P De Haro

series ordinal

2

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Jac A Nickoloff

series ordinal

3

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language of work or name

English

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publication date

January 2008

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published in

Cell Research

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volume

18

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page(s)

134-47

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issue

1

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cites work

1 reference

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 April 2017

1 reference

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

21 April 2017

1 reference

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

21 April 2017

1 reference

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 April 2017

1 reference

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

21 April 2017

1 reference

Molecular views of recombination proteins and their control

21 April 2017

1 reference

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

21 April 2017

1 reference

Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication

21 April 2017

1 reference

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

21 April 2017

1 reference

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

21 April 2017

1 reference

Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions

21 April 2017

1 reference

Processing of DNA for nonhomologous end-joining by cell-free extract

21 April 2017

1 reference

Capturing chromosome conformation

21 April 2017

1 reference

Radiobiological and genetic studies on a polyploid series (haploid to hexaploid) of Saccharomyces cerevisiae

21 April 2017

1 reference

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

21 April 2017

1 reference

NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae

21 April 2017

1 reference

Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast

21 April 2017

1 reference

The interaction of p53 with replication protein A mediates suppression of homologous recombination

21 April 2017

1 reference

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

21 April 2017

1 reference

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

21 April 2017

1 reference

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

21 April 2017

1 reference

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

21 April 2017

1 reference

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

21 April 2017

1 reference

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

21 April 2017

1 reference

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 April 2017

1 reference

Direct DNA binding by Brca1

21 April 2017

1 reference

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

21 April 2017

1 reference

Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage

21 April 2017

1 reference

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

Recombination proteins in yeast

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Evolution of the immunoglobulin heavy chain class switch recombination mechanism

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Telomeres and chromosome instability

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

DNA repair pathways involved in anaphase bridge formation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Chromosomal aberrations and genomic instability induced by topoisomerase-targeted antitumour drugs

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cellular responses to DNA damage: one signal, multiple choices

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The life and death of DNA-PK.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Role of DNA-PK in the cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The Greek Goddess, Artemis, reveals the secrets of her cleavage

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Good timing in the cell cycle for precise DNA repair by BRCA1.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Regulation of DNA repair by ubiquitylation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Nonhomologous end joining in yeast

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Repair of DNA double strand breaks by non-homologous end joining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Interfaces between the detection, signaling, and repair of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Playing for half the deck: the molecular biology of meiosis.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Chromatin structural elements and chromosomal translocations in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Activation of DNA-dependent protein kinase by single-stranded DNA ends

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cellular functions of the BRCA tumour-suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Chromosome territories--a functional nuclear landscape.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Yeast cell-type regulation of DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

A DNA microarray-based genetic screen for nonhomologous end-joining mutants in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Inactivation of p53 results in high rates of homologous recombination

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

DNA substrate dependence of p53-mediated regulation of double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

p53 in recombination and repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

P53 inhibits strand exchange and replication fork regression promoted by human Rad51.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cohesin and DNA damage repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Getting started: regulating the initiation of DNA replication in yeast

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Relative rates of homologous and nonhomologous recombination in transfected DNA.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The many interfaces of Mre11

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

gammaH2AX as a checkpoint maintenance signal.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Diverse roles for histone H2A modifications in DNA damage response pathways in yeast

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Control of sister chromatid recombination by histone H2AX.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

ATP-dependent chromatin remodeling factors and DNA damage repair

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Chromatin dynamics and the preservation of genetic information

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Protein phosphatases regulate DNA-dependent protein kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

The controlling role of ATM in homologous recombinational repair of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

ATM is required for the cellular response to thymidine induced replication fork stress.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.111

7 January 2021