Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships (Q28263229)

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Charlotte Grootaert

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object named as

Charlotte Grootaert

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Marc Bracke

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object named as

Marc Bracke

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author name string

Barbara Vanhoecke

Expert Review of Proteomics

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language of work or name

English

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publication date

April 2012

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published in

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volume

9

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issue

2

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page(s)

181-99

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cites work

Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4

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Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes.

21 January 2018

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The gut microbiota as an environmental factor that regulates fat storage

21 January 2018

1 reference

Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart.

21 January 2018

1 reference

Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans

21 January 2018

1 reference

Tissue-specific effects of valsartan on rstn and fiaf gene expression in the ob/ob mouse

21 January 2018

1 reference

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight

21 January 2018

1 reference

Food restriction regulates adipose-specific cytokines in pituitary gland but not in hypothalamus

21 January 2018

1 reference

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation

21 January 2018

1 reference

Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha

21 January 2018

1 reference

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene

21 January 2018

1 reference

Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids

21 January 2018

1 reference

Hypoxia upregulates the expression of angiopoietin-like-4 in human articular chondrocytes: role of angiopoietin-like-4 in the expression of matrix metalloproteinases and cartilage degradation.

21 January 2018

1 reference

Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat

21 January 2018

1 reference

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

21 January 2018

1 reference

Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma

21 January 2018

1 reference

Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor

21 January 2018

1 reference

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

21 January 2018

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Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing

21 January 2018

1 reference

Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways.

21 January 2018

1 reference

Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma

21 January 2018

1 reference

Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness

21 January 2018

1 reference

Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis

21 January 2018

1 reference

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

21 January 2018

1 reference

Effect of ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in human lung cancer cell lines

21 January 2018

1 reference

Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1

21 January 2018

1 reference

Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

21 January 2018

1 reference

Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism

21 January 2018

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Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome

21 January 2018

1 reference

Absence of intestinal microbiota does not protect mice from diet-induced obesity.

21 January 2018

1 reference

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

21 January 2018

1 reference

Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.

21 January 2018

1 reference

The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity

21 January 2018

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Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages

21 January 2018

1 reference

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

21 January 2018

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Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

21 January 2018

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Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

21 January 2018

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Angiopoietin-like 4 regulates epidermal differentiation

21 January 2018

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ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

21 January 2018

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Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

21 January 2018

1 reference

Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events

21 January 2018

1 reference

The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment

21 January 2018

1 reference

Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator

21 January 2018

1 reference

Transcriptional response to hypoxia in human tumors

21 January 2018

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Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation

21 January 2018

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Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation

21 January 2018

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Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

21 January 2018

1 reference

Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.

21 January 2018

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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

21 January 2018

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Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

21 January 2018

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Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production

21 January 2018

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HIF-1 and mechanisms of hypoxia sensing

21 January 2018

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Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

21 January 2018

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Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton

21 January 2018

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Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway

21 January 2018

1 reference

Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors

21 January 2018

1 reference

Adipokines: inflammation and the pleiotropic role of white adipose tissue

21 January 2018

1 reference

U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3.

21 January 2018

1 reference

21 January 2018

Lung disease and PKCs

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Protein kinase C as a stress sensor

21 January 2018

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Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3.

21 January 2018

1 reference

Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

21 January 2018

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Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells

21 January 2018

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Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4)

21 January 2018

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Metabolic endotoxemia initiates obesity and insulin resistance

21 January 2018

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Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice

21 January 2018

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Lipopolysaccharide (LPS) stimulates adipokine and socs3 gene expression in mouse brain and pituitary gland in vivo, and in N-1 hypothalamic neurons in vitro

21 January 2018

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The acute phase response stimulates the expression of angiopoietin like protein 4.

21 January 2018

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Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

21 January 2018

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HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells

21 January 2018

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Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription

21 January 2018

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Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue

21 January 2018

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Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.

21 January 2018

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A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.

21 January 2018

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Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4.

21 January 2018

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Genetic variation in ANGPTL4 provides insights into protein processing and function

21 January 2018

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Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity.

21 January 2018

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Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity

21 January 2018

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Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress

21 January 2018

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Peroxisome proliferator-activated receptor alpha target genes

21 January 2018

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Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration

21 January 2018

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The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms

21 January 2018

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Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

21 January 2018

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The G0/G1 switch gene 2 is a novel PPAR target gene.

21 January 2018

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Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

21 January 2018

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ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk

21 January 2018

1 reference

ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

21 January 2018

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15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist

21 January 2018

1 reference

All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor

21 January 2018

1 reference

Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes

21 January 2018

1 reference

Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy

21 January 2018

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Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes

21 January 2018

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Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells.

21 January 2018

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PPAR Tissue Distribution and Interactions with Other Hormone-Signaling Pathways

21 January 2018

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