Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics (Q28264943)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22517853%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics (English)

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29 January 2020

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5

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29 January 2020

author name string

James J Foti

1

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29 January 2020

Babho Devadoss

2

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29 January 2020

Jonathan A Winkler

3

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29 January 2020

James J Collins

4

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29 January 2020

language of work or name

English

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publication date

1 April 2012

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29 January 2020

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29 January 2020

volume

336

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29 January 2020

issue

6079

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29 January 2020

page(s)

315-319

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Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis

29 January 2020

cites work

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A common mechanism of cellular death induced by bactericidal antibiotics

20 March 2017

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The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

20 March 2017

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Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles

20 March 2017

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

22 April 2017

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Isolation of an E. coli Strain with a Mutation affecting DNA Polymerase

22 April 2017

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Fix the antibiotics pipeline.

22 April 2017

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Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli.

29 September 2017

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Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides

29 September 2017

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29 September 2017

Magic spot: (p) ppGpp

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Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase.

29 September 2017

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Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death.

29 September 2017

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Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.

29 September 2017

1 reference

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The nucleotide pool is a significant target for oxidative stress

29 September 2017

1 reference

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Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products

29 September 2017

1 reference

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Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools

29 September 2017

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Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections

29 September 2017

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Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function

29 September 2017

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The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity

29 September 2017

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Molecular mechanisms that confer antibacterial drug resistance

29 September 2017

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Protein oxidation in response to increased transcriptional or translational errors

29 September 2017

1 reference

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Mutants of Escherichia coli with increased fidelity of DNA replication

29 September 2017

1 reference

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Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: protective role of superoxide dismutase

29 September 2017

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Hydroxyl radical scavengers inhibit lymphocyte mitogenesis

29 September 2017

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Radiation and hydrogen peroxide induced free radical damage to DNA.

29 September 2017

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The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications

29 September 2017

1 reference

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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

2 June 2018

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Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks

2 June 2018

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A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates.

2 June 2018

1 reference

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Assessing the metabolic function of the MutT 8-oxodeoxyguanosine triphosphatase in Escherichia coli by nucleotide pool analysis

21 January 2018

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Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme.

21 January 2018

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Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme.

21 January 2018

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Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

21 January 2018

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Stoking the antibiotic pipeline.

21 January 2018

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Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1219192

Enhancing the "A-rule" of translesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates

21 January 2018

1 reference

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UmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1219192

Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli

21 January 2018

1 reference

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A bacterial G protein-mediated response to replication arrest.

21 January 2018

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The Influence of Oxygen on the Yield of DNA Double-Strand Breaks in X-Irradiated Escherichia coli K-12

21 January 2018

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12 December 2020

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical

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12 December 2020

Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

1 reference

12 December 2020

Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal

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12 December 2020

Identifiers

DOI

10.1126/SCIENCE.1219192

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22517853%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22517853%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22517853%20AND%20SRC:MED&resulttype=core&format=json