TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO (Q28266047)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json

Forkhead box protein O CELE_R13H8.1

31 January 2020

main subject

cell biology

0 references

1 reference

cytochrome C CELE_C54G4.8

1 reference

BZIP domain-containing protein;Protein skinhead-1 CELE_T19E7.2

1 reference

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein CELE_Y55D5A.5

1 reference

Protein lgg-1 CELE_C32D5.9

1 reference

Ribosomal protein S6 kinase beta CELE_Y47D3A.16

1 reference

cytochrome oxidase assembly protein CELE_F26E4.9

1 reference

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Dudley W Lamming

3

1 reference

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31 January 2020

Masaki Mizunuma

4

1 reference

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31 January 2020

David M. Sabatini

7

1 reference

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31 January 2020

author name string

Stacey Robida-Stubbs

1

1 reference

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31 January 2020

Sri Devi Narasimhan

5

1 reference

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31 January 2020

Elke Neumann-Haefelin

6

1 reference

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31 January 2020

T Keith Blackwell

8

1 reference

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31 January 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

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31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

volume

15

1 reference

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31 January 2020

page(s)

713-724

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31 January 2020

issue

5

1 reference

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

31 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity

20 March 2017

1 reference

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Activation of mTORC2 by association with the ribosome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

mTOR: from growth signal integration to cancer, diabetes and ageing

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

20 March 2017

1 reference

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Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1

20 March 2017

1 reference

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Stress-activated cap'n'collar transcription factors in aging and human disease

20 March 2017

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

20 March 2017

1 reference

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The TOR pathway comes of age

20 March 2017

1 reference

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Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

20 March 2017

1 reference

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TOR signaling in growth and metabolism

20 March 2017

1 reference

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

20 March 2017

1 reference

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

20 March 2017

1 reference

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20 March 2017

The genetics of ageing

1 reference

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Molecular mechanisms of mTOR-mediated translational control

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Genetics: influence of TOR kinase on lifespan in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Autophagy genes are essential for dauer development and life-span extension in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

The cell-non-autonomous nature of electron transport chain-mediated longevity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Termination of autophagy and reformation of lysosomes regulated by mTOR

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Two neurons mediate diet-restriction-induced longevity in C. elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Role and regulation of starvation-induced autophagy in the Drosophila fat body

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Beneficial role of Nrf2 in regulating NADPH generation and consumption

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Interplay between FOXO, TOR, and Akt.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Stressin' Sestrins take an aging fight

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

A new DAF-16 isoform regulates longevity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Reactive oxygen species enhance insulin sensitivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Establishment of a tissue-specific RNAi system in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Evolutionary conservation of regulated longevity assurance mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

Inhibition of a eukaryotic initiation factor (eIF2Bdelta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

daf-16 protects the nematode Caenorhabditis elegans during food deprivation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

DAF-16 target genes that control C. elegans life-span and metabolism.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3348514

10.1016/J.CMET.2012.04.007

27 November 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22560223%20AND%20SRC:MED&resulttype=core&format=json