Two crystal structures for cathepsin D: the lysosomal targeting signal and active site (Q28267848)

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12 October 2019

title

Two crystal structures for cathepsin D: the lysosomal targeting signal and active site (English)

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12 October 2019

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Metcalf P

1

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12 October 2019

Fusek M

series ordinal

2

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12 October 2019

language of work or name

English

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publication date

1 April 1993

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12 October 2019

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12 October 2019

volume

12

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12 October 2019

issue

4

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12 October 2019

page(s)

1293-1302

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Crystallographic R factor refinement by molecular dynamics

12 October 2019

cites work

1 reference

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Cloning and sequence analysis of cDNA for human cathepsin D

20 March 2017

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Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form

20 March 2017

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The three-dimensional structure of recombinant bovine chymosin at 2.3 A resolution

20 March 2017

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Revised 2.3 A structure of porcine pepsin: evidence for a flexible subdomain

20 March 2017

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The structure and function of the aspartic proteinases

20 March 2017

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Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution

20 March 2017

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Molecular organization of the human cathepsin D gene

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity

20 March 2017

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Human liver cathepsin D. Purification, crystallization and preliminary X-ray diffraction analysis of a lysosomal enzyme

20 March 2017

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Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes

20 March 2017

1 reference

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The biogenesis of lysosomes

20 March 2017

1 reference

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CLUSTAL V: improved software for multiple sequence alignment

7 April 2017

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Amino acid sequence of porcine spleen cathepsin D

7 April 2017

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29 September 2017

Intracellular proteases

1 reference

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Trafficking of lysosomal enzymes in normal and disease states

29 September 2017

1 reference

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Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation

29 September 2017

1 reference

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Primary structure of a barley-grain aspartic proteinase. A plant aspartic proteinase resembling mammalian cathepsin D

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Molecular recognition and targeting of lysosomal proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Lysosomal enzyme phosphorylation. II. Protein recognition determinants in either lobe of procathepsin D are sufficient for phosphorylation of both the amino and carboxyl lobe oligosaccharides

29 September 2017

1 reference

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Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Characterization of UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase from Acanthamoeba castellanii

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Evidence for lysosomal enzyme recognition by human fibroblasts via a phosphorylated carbohydrate moiety

29 September 2017

1 reference

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Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Action of cathepsin D on fructose-1,6-bisphosphate aldolase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

A systematic series of synthetic chromophoric substrates for aspartic proteinases

2 June 2018

1 reference

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Generation of a lysosomal enzyme targeting signal in the secretory protein pepsinogen.

2 June 2018

1 reference

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Expression and maturation of human cathepsin D in baby-hamster kidney cells

2 June 2018

1 reference

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Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells

2 June 2018

1 reference

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Purification and crystallization of human cathepsin D

2 June 2018

1 reference

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X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins

2 June 2018

1 reference

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Domain flexibility in aspartic proteinases

2 June 2018

1 reference

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Crystallization of human beta-hexosaminidase B

2 June 2018

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Cloning of cDNA for mosquito lysosomal aspartic protease. Sequence analysis of an insect lysosomal enzyme similar to cathepsins D and E

2 June 2018

1 reference

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Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase

2 June 2018

1 reference

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The selectivity of statine-based inhibitors against various human aspartic proteinases

2 June 2018

1 reference

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Cathepsin D and prognosis in breast cancer

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413340

Thiol protease and cathepsin D activities in selected tissues and cultured cells from normal and dystrophic mice

27 November 2018

1 reference

12 December 2020

Structures at the proteolytic processing region of cathepsin D

1 reference

12 December 2020

The selectivity of cathepsin D suggests an involvement of the enzyme in the generation of T-cell epitopes

1 reference

12 December 2020

Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues

1 reference

12 December 2020

Biological and clinical significance of cathepsin D in breast cancer

1 reference

12 December 2020

Cathepsin D is membrane-associated in macrophage endosomes

1 reference

12 December 2020

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1 reference

12 December 2020

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells

1 reference

12 December 2020

Specificity of rat liver cathepsin D

1 reference

12 December 2020

Lumenal labeling of rat hepatocyte endocytic compartments. Distribution of several acid hydrolases and membrane receptors

1 reference

12 December 2020

Purification of UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase from Acanthamoeba castellanii and identification of a subunit of the enzyme

1 reference

12 December 2020

Crystallization and initial crystallographic results for pepstatin A inhibited bovine cathepsin D

1 reference

12 December 2020

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1 reference

12 December 2020

10.1002/J.1460-2075.1993.TB05774.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8467789%20AND%20SRC:MED&resulttype=core&format=json

12 October 2019

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12 October 2019

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