Regulatory T cells exert checks and balances on self tolerance and autoimmunity (Q28267935)

Autoreactive T cells in healthy individuals

Europe PubMed Central

title

Regulatory T cells exert checks and balances on self tolerance and autoimmunity (English)

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1

Kajsa Wing

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Shimon Sakaguchi

series ordinal

2

object named as

Shimon Sakaguchi

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language of work or name

English

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publication date

January 2010

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published in

Nature Immunology

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volume

11

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page(s)

7-13

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issue

1

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cites work

1 reference

Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.

21 January 2018

1 reference

H2A- and H2E-derived CD4+CD25+ regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis.

21 January 2018

1 reference

Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells

21 January 2018

1 reference

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

21 January 2018

1 reference

Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

21 January 2018

1 reference

The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

21 January 2018

1 reference

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

21 January 2018

1 reference

12 December 2020

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

1 reference

12 December 2020

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

1 reference

12 December 2020

Cell interactions in the induction of tolerance: the role of thymic lymphocytes

1 reference

12 December 2020

Autoimmune thyroid disease induced by thyroglobulin and lipopolysaccharide is inhibited by soluble TNF receptor type I.

1 reference

12 December 2020

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

1 reference

12 December 2020

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

1 reference

12 December 2020

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

1 reference

12 December 2020

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

1 reference

12 December 2020

Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells

1 reference

12 December 2020

Regulatory T cell development in the absence of functional Foxp3.

1 reference

12 December 2020

NY-ESO-1 DNA vaccine induces T-cell responses that are suppressed by regulatory T cells.

1 reference

12 December 2020

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

1 reference

12 December 2020

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

1 reference

12 December 2020

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

12 December 2020

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

1 reference

12 December 2020

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

1 reference

12 December 2020

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

1 reference

12 December 2020

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

1 reference

12 December 2020

Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance.

1 reference

12 December 2020

Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

1 reference

12 December 2020

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

1 reference

12 December 2020

CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells

1 reference

12 December 2020

The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2.

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin

1 reference

12 December 2020

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

1 reference

12 December 2020

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

1 reference

12 December 2020

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

1 reference

12 December 2020

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells

1 reference

12 December 2020

Foxp3-dependent programme of regulatory T-cell differentiation

1 reference

12 December 2020

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

1 reference

12 December 2020

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

1 reference

12 December 2020

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

1 reference

12 December 2020

How regulatory T cells work

1 reference

12 December 2020

Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

1 reference

12 December 2020

Early events in the thymus affect the balance of effector and regulatory T cells.

1 reference

12 December 2020

Developmental regulation of Foxp3 expression during ontogeny.

1 reference

12 December 2020

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

1 reference

12 December 2020

Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions

1 reference

12 December 2020

CTLA-4 control over Foxp3+ regulatory T cell function

1 reference

12 December 2020

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

1 reference

12 December 2020

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

12 December 2020

An essential role for Scurfin in CD4+CD25+ T regulatory cells

1 reference

12 December 2020

CTLA-4-Ig regulates tryptophan catabolism in vivo.

1 reference

12 December 2020

Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects

1 reference

12 December 2020

The origin and application of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

1 reference

12 December 2020

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

1 reference

12 December 2020

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

1 reference

12 December 2020

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

1 reference

12 December 2020

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.

1 reference

12 December 2020

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

1 reference

12 December 2020

Emerging possibilities in the development and function of regulatory T cells

1 reference

12 December 2020

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

1 reference

12 December 2020

Regulatory T cells - a brief history and perspective

1 reference

12 December 2020

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions.

1 reference

12 December 2020

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

12 December 2020

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

12 December 2020

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

1 reference

12 December 2020

CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg

1 reference

12 December 2020

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

1 reference

12 December 2020

Experimental autoimmune thyroiditis induced by thyroglobulin-pulsed dendritic cells

1 reference

12 December 2020

Gene-gene interactions in the NOD mouse model of type 1 diabetes.

1 reference

12 December 2020

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

12 December 2020

A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

1 reference

12 December 2020

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

12 December 2020

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

1 reference

12 December 2020

Regulatory T cells and immune tolerance

1 reference

12 December 2020

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

1 reference

12 December 2020

Projection of an immunological self shadow within the thymus by the aire protein

1 reference

12 December 2020

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

12 December 2020

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10

1 reference

12 December 2020

Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells

1 reference

12 December 2020

Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance

1 reference

12 December 2020

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

1 reference

12 December 2020

Tolerance and autoimmunity: lessons at the bedside of primary immunodeficiencies

1 reference

12 December 2020

Control of intestinal inflammation by regulatory T cells

1 reference

12 December 2020

Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity.

1 reference

12 December 2020

Regulatory lymphocytes and intestinal inflammation.

1 reference

12 December 2020

Clonal anergy of B cells: a flexible, reversible, and quantitative concept

1 reference

12 December 2020

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

1 reference

12 December 2020

Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

1 reference

12 December 2020

FOXP3 controls regulatory T cell function through cooperation with NFAT

1 reference

12 December 2020

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

1 reference

12 December 2020

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

1 reference

12 December 2020

Self-antigen presentation by thymic stromal cells: a subtle division of labor

1 reference

12 December 2020

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

1 reference

12 December 2020

Mechanisms of foxp3+ T regulatory cell-mediated suppression

1 reference

12 December 2020

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

1 reference

12 December 2020

Early events in the thymus affect the balance of effector and regulatory T cells

1 reference

7 January 2021