Targeting NF-kappaB in Waldenstrom macroglobulinemia (Q28272373)

1

Xavier Leleu

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Antonio Sacco

Antonio Sacco

7

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Aldo M Roccaro

Aldo M Roccaro

4

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Zachary Hunter

Zachary Hunter

14

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Myles Brown

Myles Brown

20

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Kenneth C. Anderson

21

Kenneth C Anderson

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Thomas E. Witzig

18

Thomas E Witzig

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Irene Ghobrial

22

Irene M Ghobrial

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Steven P. Treon

17

Steven P Treon

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Teru Hideshima

19

Teru Hideshima

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Feda Azab

13

Feda Azab

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Mena Farag

6

Mena Farag

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Judith M Runnels

9

Judith Runnels

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Molly R Melhem

10

Molly R Melhem

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Abdelkareem Azab

12

Abdelkareem Azab

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Evdoxia Hatjiharissi

15

Evdoxia Hatjiharissi

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author name string

Jérôme Eeckhoute

2

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Xiaoying Jia

3

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Hai T Ngo

8

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Nicolas Burwick

11

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Daniel R Carrasco

The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia

16

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language of work or name

English

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publication date

15 May 2008

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published in

Blood

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volume

111

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issue

10

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page(s)

5068-77

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cites work

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Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma

20 March 2017

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Waldenström macroglobulinemia

20 March 2017

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Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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NF-kappaB in cancer: from innocent bystander to major culprit

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice.

7 April 2017

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Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer

29 September 2017

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Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom's macroglobulinemia: results of WMCTG Trial 03-248.

29 September 2017

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Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis

29 September 2017

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Bortezomib is active in patients with untreated or relapsed Waldenstrom's macroglobulinemia: a phase II study of the National Cancer Institute of Canada Clinical Trials Group

29 September 2017

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Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products

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A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

29 September 2017

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Rituximab (chimeric anti-CD20) sensitizes B-NHL cell lines to Fas-induced apoptosis

29 September 2017

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Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma

29 September 2017

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Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention

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Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis.

29 September 2017

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Advances in biology of multiple myeloma: clinical applications

29 September 2017

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Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies

29 September 2017

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Novel biologically based therapies for Waldenstrom's macroglobulinemia

29 September 2017

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Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia

29 September 2017

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

29 September 2017

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

29 September 2017

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ChIP-chip: a genomic approach for identifying transcription factor binding sites

29 September 2017

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Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

29 September 2017

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NF-kappa B as a therapeutic target in multiple myeloma

29 September 2017

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

29 September 2017

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Phosphatidylinositol 3-kinases in tumor progression

29 September 2017

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The ubiquitin-proteasome pathway in cancer

29 September 2017

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

29 September 2017

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The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins.

29 September 2017

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A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity

29 September 2017

1 reference

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The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms

2 June 2018

1 reference

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Proteomic Analysis of Waldenstrom Macroglobulinemia

2 June 2018

1 reference

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Dysregulation of apoptosis in Waldenstrom's macroglobulinemia does not involve nuclear factor kappa B activation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384134

Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384134

The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384134

Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384134

Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia and does not correlate with p65 NF-kappaB activation

27 November 2018

1 reference

12 December 2020

Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling

1 reference

12 December 2020

Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia

1 reference

12 December 2020

Waldenström macroglobulinemia

1 reference

12 December 2020

10.1182/BLOOD-2007-09-115170

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DOI

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Fatcat ID

release_sizhbsvfcngqxh7i6a42s47avm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sizhbsvfcngqxh7i6a42s47avm

24 November 2022