Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein (Q28273516)

4

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author name string

V Brown

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K Small

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L Lakkis

3

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K D Wilkinson

6

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S T Warren

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

19 June 1998

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published in

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volume

273

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issue

25

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page(s)

15521-7

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cites work

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The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

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FMR1 protein: conserved RNP family domains and selective RNA binding

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Conserved structures and diversity of functions of RNA-binding proteins

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The fragile X mental retardation protein is associated with ribosomes

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FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

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Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them

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