Tyrosine hydroxylase and Parkinson's disease (Q28273702)

Melanin formation in the inner ear is catalyzed by a new tyrosine hydroxylase kinetically and structurally different from tyrosinase.

Europe PubMed Central

title

Tyrosine hydroxylase and Parkinson's disease (English)

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J Haavik

1

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author name string

K Toska

series ordinal

2

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language of work or name

English

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publication date

June 1998

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published in

Molecular Neurobiology

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volume

16

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issue

3

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page(s)

285-309

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cites work

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Characterization of the active site iron in tyrosine hydroxylase. Redox states of the iron

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Catalytic core of rat tyrosine hydroxylase: terminal deletion analysis of bacterially expressed enzyme.

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Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells.

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12 December 2020

Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease

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12 December 2020

Genetic factors in the etiology of idiopathic Parkinson's disease

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12 December 2020

Post-transcriptional regulation of tyrosine hydroxylase gene expression by oxygen in PC12 cells

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12 December 2020

Suppression of hydroxyl radical formation and protection of nigral neurons by l-deprenyl (selegiline)

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12 December 2020

Biological origin of free radicals, and mechanisms of antioxidant protection

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12 December 2020

Deficiency of tyrosine hydroxylase or tryptophan hydroxylase: a possible cause of two hypothetical metabolic diseases

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12 December 2020

Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases

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12 December 2020

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

1 reference

12 December 2020

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

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12 December 2020

Melanin formation by human brain in vitro

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12 December 2020

Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts

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12 December 2020

Pterin-Dependent Amino Acid Hydroxylases

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12 December 2020

Oxidative stress, glutamate, and neurodegenerative disorders

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12 December 2020

Neurobiology. Better cells for brain repair.

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12 December 2020

The 'common deletion' is not increased in parkinsonian substantia nigra as shown by competitive polymerase chain reaction.

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12 December 2020

DOPA compared with dihydroxyfumarate as co-factor in peroxidase-mediated oxidation of tyrosine to melanin. Histochemical studies with neutrophils, eosinophils, mast cells, melanoma cells and neurons

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12 December 2020

Generation of reactive oxygen species by tyrosine hydroxylase: a possible contribution to the degeneration of dopaminergic neurons?

1 reference

12 December 2020

Mutations in the copper- and zinc-containing superoxide dismutase gene are associated with "Lou Gehrig's disease"

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12 December 2020

Multiple signaling pathways in bovine chromaffin cells regulate tyrosine hydroxylase phosphorylation at Ser19, Ser31, and Ser40

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12 December 2020

Development and application of herpes simplex virus vectors for human gene therapy

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12 December 2020

Glutathione peroxidase, glial cells and Parkinson's disease.

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12 December 2020

The stress activated protein kinase pathway

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12 December 2020

Oxidative inactivation of tyrosine hydroxylase in substantia nigra of aged rat

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12 December 2020

Protein kinase cascades activated by stress and inflammatory cytokines

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12 December 2020

Increased nigral iron content in postmortem parkinsonian brain.

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12 December 2020

Possible genotoxicity of melanin synthesis intermediates: tyrosinase reaction products interact with DNA in vitro

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12 December 2020

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

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12 December 2020

The histochemical relationship of neuromelanin and lipofuscin.

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12 December 2020

Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease

1 reference

12 December 2020

Dopa-responsive dystonia

1 reference

12 December 2020

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

12 December 2020

Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases.

1 reference

12 December 2020

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

1 reference

12 December 2020

Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia

1 reference

12 December 2020

Human gene for torsion dystonia located on chromosome 9q32-q34.

1 reference

12 December 2020

Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia

1 reference

12 December 2020

Identification of iron ligands in tyrosine hydroxylase by mutagenesis of conserved histidinyl residues

1 reference

12 December 2020

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

1 reference

12 December 2020

The TiPS/TINS lecture. Catecholamines: from gene regulation to neuropsychiatric disorders

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12 December 2020

Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts

1 reference

12 December 2020

Tyrosine hydroxylase polymorphism in familial and sporadic Parkinson's disease

1 reference

12 December 2020

Fetal nigral transplantation as a therapy for Parkinson's disease

1 reference

12 December 2020

A dual role for the cAMP-dependent protein kinase in tyrosine hydroxylase gene expression

1 reference

12 December 2020

Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Regulation of tyrosine hydroxylase gene expression by the m1 muscarinic acetylcholine receptor in rat pheochromocytoma cells

1 reference

12 December 2020

α-synuclein—a link between Parkinson and Alzheimer diseases?

1 reference

12 December 2020

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

1 reference

12 December 2020

Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR

1 reference

12 December 2020

pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40

1 reference

12 December 2020

Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid

1 reference

12 December 2020

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

1 reference

12 December 2020

A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing.

1 reference

12 December 2020

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1 reference

12 December 2020

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

1 reference

12 December 2020

Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites.

1 reference

12 December 2020

The stability of endogenous tyrosine hydroxylase protein in PC-12 cells differs from that expressed in mouse fibroblasts by gene transfer

1 reference

12 December 2020

A large kindred with autosomal dominant Parkinson's disease

1 reference

12 December 2020

Viral vectors for modulating gene expression in neurons

1 reference

12 December 2020

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1 reference

12 December 2020

Four isoforms of tyrosine hydroxylase are expressed in human brain

1 reference

12 December 2020

TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS

1 reference

12 December 2020

Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase.

1 reference

12 December 2020

Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies

1 reference

12 December 2020

Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells

1 reference

12 December 2020

Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons.

1 reference

12 December 2020

Transport of iron in the blood-brain-cerebrospinal fluid system.

1 reference

12 December 2020

Potential of neural "stem-like" cells for gene therapy and repair of the degenerating central nervous system

1 reference

12 December 2020

Renal and neuronal abnormalities in mice lacking GDNF

1 reference

12 December 2020

Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22.

1 reference

12 December 2020

Intricate regulation of tyrosine hydroxylase activity and gene expression

1 reference

12 December 2020

Monoamine oxidase, dopamine and Parkinson's disease

1 reference

12 December 2020

GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-OHDA-lesioned rats

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Superoxide dismutase, aging, and degenerative disease

1 reference

12 December 2020

Bovine tyrosine hydroxylase gene-promoter regions involved in basal and angiotensin II-stimulated expression in nontransformed adrenal medullary cells.

1 reference

12 December 2020

BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine

1 reference

12 December 2020

Mammalian tyrosinase--the critical regulatory control point in melanocyte pigmentation

1 reference

12 December 2020

Dopa-responsive dystonia: pathological and biochemical observations in a case.

1 reference

12 December 2020

Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release

1 reference

12 December 2020

Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system

1 reference

12 December 2020

Thermal stability and CD analysis of rat tyrosine hydroxylase

1 reference

12 December 2020

A parkinsonian kindred

1 reference

12 December 2020

Studies on the possible mechanism of inactivation of phenylalanine hydroxylase by destructive oxygen species

1 reference

12 December 2020

Oxidative stress and antioxidant therapy in Parkinson's disease

1 reference

12 December 2020

Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease

1 reference

12 December 2020

Genetic linkage studies in autosomal dominant parkinsonism: evaluation of seven candidate genes

1 reference

12 December 2020

Cerebrospinal fluid homovanillic acid in the DATATOP study on Parkinson's disease. Parkinson Study Group

1 reference

12 December 2020

A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome

1 reference

12 December 2020

Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene

1 reference

12 December 2020

Mössbauer, electron-paramagnetic-resonance and X-ray-absorption fine-structure studies of the iron environment in recombinant human tyrosine hydroxylase.

1 reference

12 December 2020

Site-directed mutagenesis of tyrosine hydroxylase. Role of serine 40 in catalysis

1 reference

12 December 2020

A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines

1 reference

12 December 2020

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.

1 reference

12 December 2020

Parallel signal processing among mammalian MAPKs

1 reference

12 December 2020

A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics

1 reference

12 December 2020

The GTP-cyclohydrolase I gene in atypical parkinsonian patients: a clinico-genetic study

1 reference

12 December 2020

Neural-targeted gene therapy for rodent and primate hemiparkinsonism

1 reference

12 December 2020

Environment, genetics and idiopathic Parkinson's disease

1 reference

12 December 2020

Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain

1 reference

12 December 2020

[Segawa disease (hereditary progressive dystonia with marked diurnal fluctuation-HPD) and abnormalities in pteridin metabolism]

1 reference

12 December 2020

Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: a nuclear microscopy study.

1 reference

12 December 2020

Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase

1 reference

12 December 2020

Regulation of recombinant human tyrosine hydroxylase isozymes by catecholamine binding and phosphorylation. Structure/activity studies and mechanistic implications.

1 reference

12 December 2020

Dystonia-parkinsonism syndrome (XDP) locus: flanking markers in Xq12-q21.1

1 reference

12 December 2020

L-DOPA is a substrate for tyrosine hydroxylase

1 reference

12 December 2020

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.

1 reference

12 December 2020

Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions

1 reference

12 December 2020

Regional heterogeneity of mtDNA heteroplasmy in parkinsonian brain.

1 reference

12 December 2020

Does oxidative stress participate in nerve cell death in Parkinson's disease?

1 reference

12 December 2020

Quantitation of a mitochondrial DNA deletion in Parkinson's disease

1 reference

12 December 2020

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

12 December 2020

Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene

1 reference

12 December 2020

A novel rat tyrosine hydroxylase mRNA species generated by alternative splicing.

1 reference

12 December 2020

New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy

1 reference

12 December 2020

Resonance Raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase). Evidence that the feedback inhibitors adrenaline and noradrenaline are coordinated to iron.

1 reference

12 December 2020

In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum

1 reference

12 December 2020

Regulation of N-terminus-deleted human tyrosine hydroxylase type 1 by end products of catecholamine biosynthetic pathway

1 reference

12 December 2020

Localization of the gene for rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration to chromosome 17q21

1 reference

12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

12 December 2020

L-Dopa and dopamine-producing gene cassettes for gene therapy approaches to Parkinson's disease

1 reference

12 December 2020

Isolation and characterization of tetrahydropterin oxidation products generated in the tyrosine 3-monooxygenase (tyrosine hydroxylase) reaction

1 reference

12 December 2020

Biochemistry of Parkinson's disease with special reference to the dopaminergic systems.

1 reference

12 December 2020

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

1 reference

12 December 2020

Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium.

1 reference

12 December 2020

Peroxynitrite‐Mediated Inhibition of DOPA Synthesis in PC12 Cells

1 reference

12 December 2020

The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy

1 reference

12 December 2020

Dopa-responsive dystonia in British patients: new mutations of the GTP-cyclohydrolase I gene and evidence for genetic heterogeneity

1 reference

12 December 2020

BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons

1 reference

12 December 2020

7-substituted pterins in humans with suspected pterin-4a-carbinolamine dehydratase deficiency. Mechanism of formation via non-enzymatic transformation from 6-substituted pterins

1 reference

12 December 2020

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

1 reference

12 December 2020

Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson model

1 reference

12 December 2020

Resonance Raman Studies of Catecholate and Phenolate Complexes of Recombinant Human Tyrosine Hydroxylase

1 reference

12 December 2020

Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease

1 reference

12 December 2020

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1 reference

12 December 2020

Regulation of tyrosine hydroxylase gene expression in depolarized non-transformed bovine adrenal medullary cells: second messenger systems and promoter mechanisms.

1 reference

12 December 2020

The metal requirement of rat tyrosine hydroxylase

1 reference

12 December 2020

Reconstruction of the nigrostriatal pathway by simultaneous intrastriatal and intranigral dopaminergic transplants

1 reference

12 December 2020

Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase

1 reference

12 December 2020

Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

1 reference

12 December 2020

Regulation of L-DOPA production by genetically modified primary fibroblasts transfected with retrovirus vector system

1 reference

12 December 2020

Specific A10 dopaminergic nuclei in the midbrain degenerate in Parkinson's disease.

1 reference

12 December 2020

The effect of age on the activity and molecular properties of human brain monoamine oxidase

1 reference

12 December 2020

Reactive oxygen species: relation to aging and neurotoxic damage

1 reference

12 December 2020

Free radicals as mediators of tissue injury and disease

1 reference

12 December 2020

Free radicals in brain metabolism and pathology

1 reference

12 December 2020

Targeted vectors for gene therapy.

1 reference

12 December 2020

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

1 reference

12 December 2020

Understanding Parkinson's disease.

1 reference

12 December 2020

Deprenyl induces the tyrosine hydroxylase enzyme in the rat dopaminergic nigrostriatal system.

1 reference

12 December 2020

Tyrosine hydroxylase gene expression in varying forms of human pheochromocytoma

1 reference

12 December 2020

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

1 reference

12 December 2020

Deletion mutagenesis of rat PC12 tyrosine hydroxylase regulatory and catalytic domains.

1 reference

12 December 2020

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1 reference

12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

12 December 2020

Superoxide dismutase partially prevents sympathetic denervation by 6-hydroxydopamine.

1 reference

12 December 2020

Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase. Effects of dopamine and cAMP-dependent phosphorylation on enzyme activity

1 reference

12 December 2020

Neural stem cells for CNS transplantation

1 reference

12 December 2020

Mutations in the GTP cyclohydrolase I and 6-pyruvoyl-tetrahydropterin synthase genes

1 reference

12 December 2020

The phenylalanine hydroxylase locus: a marker for the history of phenylketonuria and human genetic diversity. PAH Mutation Analysis Consortium.

1 reference

12 December 2020

Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad

1 reference

12 December 2020

Oxidative stress as a cause of Parkinson's disease

1 reference

12 December 2020

Conversion of tyrosine hydroxylase to stable and inactive form by the end products.

1 reference

12 December 2020

Effects of Brain-derived Neurotrophic Factor on 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in Monkeys

1 reference

12 December 2020

A novel adenovirus-adeno-associated virus hybrid vector that displays efficient rescue and delivery of the AAV genome

1 reference

12 December 2020

Effect of deprenyl on the progression of disability in early Parkinson's disease

1 reference

12 December 2020

Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology

1 reference

12 December 2020

The roles of neuromelanin, binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: a hypothesis

1 reference

12 December 2020