GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling (Q28277702)

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12 June 2020

Bianca Plouffe

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Arun K Shukla

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Franziska M Heydenreich

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Michel Bouvier

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Robert J Lefkowitz

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Ryan T Strachan

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author name string

Thomas J Cahill

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Jeffrey T Tarrasch

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Annie M Dosey

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Alem W Kahsai

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12 June 2020

Biswaranjan Pani

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12 June 2020

Jacob P Mahoney

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12 June 2020

Liyin Huang

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Billy Breton

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Roger K Sunahara

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Georgios Skiniotis

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language of work or name

English

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publication date

11 August 2016

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published in

Cell

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volume

166

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issue

4

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12 June 2020

page(s)

907-919

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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

12 June 2020

cites work

1 reference

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Visualization of arrestin recruitment by a G-protein-coupled receptor

26 May 2017

1 reference

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The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization

26 May 2017

1 reference

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Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

26 May 2017

1 reference

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

26 May 2017

1 reference

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Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

26 May 2017

1 reference

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Regulation of receptor trafficking by GRKs and arrestins

26 May 2017

1 reference

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Seven-transmembrane receptors

26 May 2017

1 reference

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Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*

26 May 2017

1 reference

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Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

G proteins: transducers of receptor-generated signals

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Conformational biosensors reveal GPCR signalling from endosomes.

29 September 2017

1 reference

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Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Differential association of receptor-Gβγ complexes with β-arrestin2 determines recycling bias and potential for tolerance of δ opioid receptor agonists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Retromer terminates the generation of cAMP by internalized PTH receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418658

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.

29 September 2017

1 reference

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beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics

29 September 2017

1 reference

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Resonance energy transfer approaches in molecular pharmacology and beyond

29 September 2017

1 reference

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Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association

29 September 2017

1 reference

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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

29 September 2017

1 reference

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Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

29 September 2017

1 reference

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Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity.

29 September 2017

1 reference

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2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy

29 September 2017

1 reference

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Crystal structure of a common GPCR-binding interface for G protein and arrestin

2 June 2018

1 reference

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Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

2 June 2018

1 reference

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Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis

2 June 2018

1 reference

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Evidence that ICI 118, 551 is a potent, highly Beta 2-selective adrenoceptor antagonist and can be used to characterize Beta-adrenoceptor populations in tissues.

2 June 2018

1 reference

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CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.

20 June 2018

1 reference

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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

28 July 2018

1 reference

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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

27 November 2018

1 reference

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10.1016/J.CELL.2016.07.004

27 November 2018

Identifiers

DOI

1 reference

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12 June 2020

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12 June 2020

PubMed publication ID

27499021

1 reference