Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. (Q46017179)

18 December 2017

title

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. (English)

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18 December 2017

main subject

FTY720-phosphate

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ChEBI release 2020-05-28

3

Cihan Cetin

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18 December 2017

Florian Mullershausen

1

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18 December 2017

Frédéric Zecri

2

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18 December 2017

Andreas Billich

4

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18 December 2017

Danilo Guerini

5

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18 December 2017

Klaus Seuwen

6

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18 December 2017

publication date

1 June 2009

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18 December 2017

published in

Nature Chemical Biology

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18 December 2017

volume

5

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18 December 2017

issue

6

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18 December 2017

page(s)

428-434

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18 December 2017

https://scigraph.springernature.com/pub.10.1038/nchembio.173

exact match

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cites work

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

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FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homin

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12 December 2020

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

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12 December 2020

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A pertussis toxin-sensitive process controls thymocyte emigration

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Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

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FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.

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Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

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Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.

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Erythrocytes store and release sphingosine 1-phosphate in blood.

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12 December 2020

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12 December 2020

FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine produ

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12 December 2020

Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

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12 December 2020

Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer

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12 December 2020

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Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

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Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening

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Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

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12 December 2020

Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin

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12 December 2020

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

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12 December 2020

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

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12 December 2020

Surfing on a retrograde wave: how does Shiga toxin reach the endoplasmic reticulum?

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.173

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18 December 2017

PubMed ID

19430484

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18 December 2017