SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation (Q28282761)

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria

Europe PubMed Central

title

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation (English)

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author name string

Deepika Ahuja

series ordinal

1

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M Teresa Sáenz-Robles

series ordinal

2

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James M Pipas

series ordinal

3

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language of work or name

English

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publication date

21 November 2005

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published in

Oncogene

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volume

24

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issue

52

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page(s)

7729-45

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cites work

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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

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Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

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The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone

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Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

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Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

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Hsp70 chaperones: cellular functions and molecular mechanism

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Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

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CBP/p300 histone acetyl-transferase activity is important for the G1/S transition

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7 January 2021

Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter

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7 January 2021

Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice

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7 January 2021

Cellular transformation by SV40 large T antigen: interaction with host proteins

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7 January 2021

Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation

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7 January 2021

SV40 and Human Tumors

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7 January 2021

Development of colonic and pancreatic endocrine tumours in mice expressing a glucagon-SV40 T antigen transgene

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7 January 2021

The E2F family: specific functions and overlapping interests

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7 January 2021

The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

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7 January 2021

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

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7 January 2021

Regions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts

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7 January 2021

Hyperplasia and tumors of the islets of Langerhans in mice bearing an elastase I-SV40 T-antigen fusion gene

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7 January 2021

Interaction between T antigen and TEA domain of the factor TEF-1 derepresses simian virus 40 late promoter in vitro: identification of T-antigen domains important for transcription control

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7 January 2021

Inducible and reversible beta-cell autoimmunity and hyperplasia in transgenic mice expressing a conditional oncogene

1 reference

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7 January 2021

MDM2 is a central node in the p53 pathway: 12 years and counting

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7 January 2021

DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication

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7 January 2021

Use of normal and transgenic mice to examine the relationship between terminal differentiation of intestinal epithelial cells and accumulation of their cell cycle regulators

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7 January 2021

Diversity, topographic differentiation, and positional memory in human fibroblasts

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7 January 2021

Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Uniform cell-autonomous tumorigenesis of the choroid plexus by papovavirus large T antigens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The p53 response: emerging levels of co-factor complexity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The E2F transcriptional network: old acquaintances with new faces

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Association of p300 and CBP with simian virus 40 large T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic alpha cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Biochemical properties of a transforming nonkaryophilic T antigen of SV40.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Molecular mechanisms of E2F-dependent activation and pRB-mediated repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Development of tumors in hamsters inoculated in the neonatal period with vacuolating virus, SV-40.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Prostate cancer in a transgenic mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Transcriptional activation by simian virus 40 large T antigen: interactions with multiple components of the transcription complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Targeted expression of SV40 large T-antigen to visceral smooth muscle induces proliferation of contractile smooth muscle cells and results in megacolon

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Molecular mechanisms of enteroendocrine differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Chaperone power in a virus?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Oncogenesis of the lens in transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

p53 and SV40 T antigen bind to the same region overlapping the conserved domain of the TATA-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Role of T antigen interactions with p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Mutational Analysis of Simian Virus 40 T Antigen: Isolation and Characterization of Mutants with Deletions in the T-Antigen Gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

p53 targets simian virus 40 large T antigen for acetylation by CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

DNA-Binding Properties of Simian Virus 40 T-Antigen Mutants Defective in Viral DNA Replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

hBUB1 defects in leukemia and lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Inhibition of Rb and p53 is insufficient for SV40 T-antigen transformation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Transforming functions of Simian Virus 40.

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7 January 2021

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

SV40 large T antigen functions at two distinct steps in virion assembly

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 infection disrupts p130-E2F and p107-E2F complexes but does not perturb pRb-E2F complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Two regions of simian virus 40 large T-antigen independently extend the life span of primary C57BL/6 mouse embryo fibroblasts and cooperate in immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The SV40 T antigen modulates CBP histone acetyltransferase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Cancer modeling in the modern era: progress and challenges

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7 January 2021

Genetic alterations during colorectal-tumor development

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7 January 2021

The tumor-suppressive functions of the human INK4A locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209046

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209046

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1785522

1017838792

0 references

1785522

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference