The hexosamine signaling pathway: deciphering the "O-GlcNAc code" (Q28284365)

Science's STKE : signal transduction knowledge environment

Europe PubMed Central

title

The hexosamine signaling pathway: deciphering the "O-GlcNAc code" (English)

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author name string

Dona C Love

series ordinal

1

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John A Hanover

series ordinal

2

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language of work or name

English

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publication date

29 November 2005

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published in

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volume

2005

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issue

312

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page(s)

re13

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cites work

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A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance

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Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

21 January 2018

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Monoclonal antibodies identify a group of nuclear pore complex glycoproteins

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21 January 2018

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21 January 2018

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21 January 2018

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Homology between O-linked GlcNAc transferases and proteins of the glycogen phosphorylase superfamily

21 January 2018

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Prediction of structure and functional residues for O-GlcNAcase, a divergent homologue of acetyltransferases

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Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1.

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O-GlcNAc modification is an endogenous inhibitor of the proteasome

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21 January 2018

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Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction

21 January 2018

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The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells.

21 January 2018

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21 January 2018

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Neuroendocrine mechanisms involved in regulation of body weight, food intake and metabolism

21 January 2018

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Induction of cytochrome P-450 RNA by porphyrogenic agents: on the nature of the coordinate induction with delta-aminolevulinate synthase in tissues of the chicken embryo

21 January 2018

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Development of insulin resistance in 3T3-L1 adipocytes

21 January 2018

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21 January 2018

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

21 January 2018

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Development and comparison of two 3T3-L1 adipocyte models of insulin resistance: increased glucose flux vs glucosamine treatment

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High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes

21 January 2018

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Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation

21 January 2018

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Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles

21 January 2018

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Role of the glucosamine pathway in fat-induced insulin resistance

21 January 2018

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

21 January 2018

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Timing requirements for insulin/IGF-1 signaling in C. elegans

21 January 2018

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Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

21 January 2018

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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

21 January 2018

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Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress

21 January 2018

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21 January 2018

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Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians

21 January 2018

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A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans

21 January 2018

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Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.

21 January 2018

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Assignment of N-acetyl-D-glucosaminidase (Mgea5) to rat chromosome 1q5 by tyramide fluorescence in situ hybridization (T-FISH): synteny between rat, mouse and human with Insulin Degradation Enzyme (IDE).

21 January 2018

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Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats

21 January 2018

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Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance

21 January 2018

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Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

21 January 2018

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Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

21 January 2018

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Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.

21 January 2018

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Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex

21 January 2018

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Beta-amyloid precursor protein is modified with O-linked N-acetylglucosamine.

21 January 2018

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Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

21 January 2018

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O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

21 January 2018

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Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease.

21 January 2018

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Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease.

21 January 2018

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Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability

21 January 2018

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Alzheimer's disease: clues from flies and worms

21 January 2018

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

21 January 2018

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Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals

21 January 2018

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Transgenic animal models of tauopathies

21 January 2018

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Neurodegenerative tauopathy in the worm

21 January 2018

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Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

21 January 2018

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The origins of protein phosphorylation

21 January 2018

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O-GlcNAc: a regulatory post-translational modification.

21 January 2018

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Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.

21 January 2018

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Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection

21 January 2018

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The capsid protein of a plant single-stranded RNA virus is modified by O-linked N-acetylglucosamine

21 January 2018

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Two transcription factors are negative regulators of gibberellin response in the HvSPY-signaling pathway in barley aleurone

21 January 2018

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Identification of a negative regulator of gibberellin action, HvSPY, in barley.

21 January 2018

1 reference

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SPINDLY is a nuclear-localized repressor of gibberellin signal transduction expressed throughout the plant

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1126/STKE.3122005RE13

1 reference

Consolidated OpenCitations Corpus – April 2017

2245949

2245949

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference