Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction (Q33920091)

30 July 2017

Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction (English)

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30 July 2017

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Biljana Musicki

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30 July 2017

Melissa F Kramer

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2

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30 July 2017

Robyn E Becker

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3

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30 July 2017

Arthur L Burnett

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4

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30 July 2017

language of work or name

English

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publication date

5 August 2005

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

102

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30 July 2017

11870-11875

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30 July 2017

33

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Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

The Akt kinase signals directly to endothelial nitric oxide synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Phosphorylated Endothelial Nitric Oxide Synthase Mediates Vascular Endothelial Growth Factor-Induced Penile Erection1

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Changes in mating behavior, erectile function, and nitric oxide levels in penile corpora cavernosa in streptozotocin-diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

The effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Vascular endothelial growth factor causes endothelial proliferation after vascular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Altered Sonic Hedgehog Signaling Is Associated with Morphological Abnormalities in the Penis of the BB/WOR Diabetic Rat1

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

The role of free radical in the pathogenesis of impotence in streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0502488102

Oxidative stress and antioxidant therapy: their impact in diabetes-associated erectile dysfunction

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1187969

29 October 2018

1 reference

12 December 2020

Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E

1 reference

12 December 2020

Nitric oxide: a physiologic mediator of penile erection

1 reference

12 December 2020

Superoxide anion and endothelial regulation of arterial tone

1 reference

12 December 2020

Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0502488102

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30 July 2017

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30 July 2017

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