Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study (Q28287860)

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English	Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study	scientific article

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scholarly article

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Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study (English)

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Kayode Ogungbenro

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Kayode Ogungbenro

2

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Stephen J. Hopkins

object named as

Stephen J Hopkins

10

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Pippa J Tyrrell

object named as

Pippa Tyrrell

12

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11

object named as

Nancy Rothwell

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author name string

James Galea

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Sharon Hulme

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Andrew Greenhalgh

4

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Leon Aarons

5

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Sylvia Scarth

6

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Peter Hutchinson

7

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Samantha Grainger

8

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Andrew King

9

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publication date

February 2011

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Journal of Cerebral Blood Flow & Metabolism

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31

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2

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439-47

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Calcium antagonists for aneurysmal subarachnoid haemorrhage

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Time Is Brain--Quantified

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1,026 experimental treatments in acute stroke

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Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

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Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism

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Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons.

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Peripheral administration of Interleukin-1 Receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat.

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Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.

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IV tissue plasminogen activator use in acute stroke: experience from a statewide registry.

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Eligibility for recombinant tissue plasminogen activator in acute ischemic stroke: way to endeavor.

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Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study.

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Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat.

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Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

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The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments.

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Predictors of cerebral infarction in aneurysmal subarachnoid hemorrhage.

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Prompt response of refractory Schnitzler syndrome to treatment with anakinra.

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Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis.

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Delay in presentation and evaluation for acute stroke: Stroke Time Registry for Outcomes Knowledge and Epidemiology (S.T.R.O.K.E.).

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Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled

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https://pubmed.ncbi.nlm.nih.gov/20628399

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Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628399

12 December 2020

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Identifiers

10.1038/JCBFM.2010.103

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