RIP1, a kinase on the crossroads of a cell's decision to live or die (Q28288337)

Cell Death & Differentiation

Europe PubMed Central

title

RIP1, a kinase on the crossroads of a cell's decision to live or die (English)

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N Festjens

1

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Peter Vandenabeele

object named as

P Vandenabeele

series ordinal

4

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author name string

T Vanden Berghe

series ordinal

2

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S Cornelis

series ordinal

3

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language of work or name

English

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publication date

March 2007

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published in

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volume

14

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issue

3

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page(s)

400-10

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cites work

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Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

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Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

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Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

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Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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Signals from within: the DNA-damage-induced NF-kappaB response

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

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Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

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Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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The RIP kinases: crucial integrators of cellular stress

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LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain

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The Parkinson disease gene LRRK2: evolutionary and structural insights

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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

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7 January 2021

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles

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7 January 2021

TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

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7 January 2021

The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase

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7 January 2021

Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

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7 January 2021

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

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7 January 2021

TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

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7 January 2021

Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis

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7 January 2021

Non-apoptotic Fas signaling.

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7 January 2021

NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

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7 January 2021

Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells

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7 January 2021

Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

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7 January 2021

The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase

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7 January 2021

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

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Caspase-independent cell killing by Fas-associated protein with death domain

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7 January 2021

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

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7 January 2021

Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.

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7 January 2021

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

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7 January 2021

Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response

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7 January 2021

Ceramide mediates caspase-independent programmed cell death

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7 January 2021

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

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7 January 2021

Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

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7 January 2021

Autophagic programmed cell death by selective catalase degradation

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7 January 2021

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

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7 January 2021

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

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7 January 2021

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

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7 January 2021

Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways

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7 January 2021

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

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7 January 2021

Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages

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7 January 2021

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

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7 January 2021

NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein

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7 January 2021

Autophagy contributes to caspase-independent macrophage cell death

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7 January 2021

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

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7 January 2021

Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation

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7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

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7 January 2021

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

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7 January 2021

Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death

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7 January 2021

TLR3 in antiviral immunity: key player or bystander?

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7 January 2021

A FADD-dependent innate immune mechanism in mammalian cells

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7 January 2021

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7 January 2021

Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

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7 January 2021

PIDD mediates NF-kappaB activation in response to DNA damage

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7 January 2021

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

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7 January 2021

The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death

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7 January 2021

Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

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7 January 2021

Caspases leave the beaten track: caspase-mediated activation of NF-kappaB.

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7 January 2021

Cell biology. Kinasing and clipping down the NF-kappa B trail

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7 January 2021

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

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7 January 2021

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

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7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

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7 January 2021

Inhibition of NFkappaB induces caspase-independent cell death in human T lymphocytes

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7 January 2021

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder

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7 January 2021