Engineering GPCR signaling pathways with RASSLs (Q28289158)

G protein-coupled receptor

Europe PubMed Central

title

Engineering GPCR signaling pathways with RASSLs (English)

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main subject

cell biology

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author

Joël Bockaert

13

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author name string

Bruce R Conklin

1

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Edward C Hsiao

2

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Sylvie Claeysen

3

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Aline Dumuis

4

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Supriya Srinivasan

5

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John R Forsayeth

6

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Jean-Marc Guettier

7

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W C Chang

8

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Ying Pei

9

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Ken D McCarthy

10

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Robert A Nissenson

11

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Jürgen Wess

12

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Bryan L Roth

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

14

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language of work or name

English

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publication date

August 2008

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published in

Nature Methods

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volume

5

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page(s)

673-8

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issue

8

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cites work

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20 March 2017

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20 March 2017

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7 April 2017

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Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.

29 September 2017

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29 September 2017

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A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.

29 September 2017

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2 June 2018

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Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes.

2 June 2018

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A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL).

27 November 2018

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A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

27 November 2018

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27 November 2018

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27 November 2018

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