Rapid identification of functionally critical amino acids in a G protein-coupled receptor. (Q54563990)

1 June 2018

title

Rapid identification of functionally critical amino acids in a G protein-coupled receptor. (English)

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1 June 2018

G protein-coupled receptor

main subject

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2

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Kenneth A. Jacobson

5

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author name string

Bo Li

1

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1 June 2018

Christopher D Knudsen

3

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Soo-Kyung Kim

4

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Sara M McMillin

6

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Jürgen Wess

7

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1 June 2018

publication date

7 January 2007

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1 June 2018

published in

Nature Methods

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1 June 2018

volume

4

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issue

2

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page(s)

169-174

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https://scigraph.springernature.com/pub.10.1038/nmeth990

exact match

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cites work

Seven-transmembrane receptors

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Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function

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Molecular basis of receptor/G-protein-coupling selectivity

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G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

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Yeast Assays for G-Protein-Coupled Receptors

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Techniques: how to boost GPCR mutagenesis studies using yeast

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The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization

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Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

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7 January 2021

Genetic interactions among the transmembrane segments of the G protein coupled receptor encoded by the yeast STE2 gene

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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

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7 January 2021

Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis

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7 January 2021

Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling

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7 January 2021

Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.

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7 January 2021

Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast

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7 January 2021

Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor

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7 January 2021

Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling

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7 January 2021

Model systems for the study of seven-transmembrane-segment receptors

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A review of phenotypes in Saccharomyces cerevisiae

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Recombination-mediated PCR-directed plasmid construction in vivo in yeast

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Seven-transmembrane receptors: crystals clarify

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7 January 2021

Scanning mutagenesis studies of the M1 muscarinic acetylcholine receptor

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7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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7 January 2021

Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor

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7 January 2021

Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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7 January 2021

Identifiers

DOI

10.1038/NMETH990

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1 June 2018

PubMed ID

17206152

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1 June 2018