The emerging roles of human tissue kallikreins in cancer (Q28290701)

The microenvironment of the tumour-host interface

Europe PubMed Central

title

The emerging roles of human tissue kallikreins in cancer (English)

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author

Eleftherios P. Diamandis

series ordinal

2

object named as

Eleftherios P Diamandis

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author name string

Carla A Borgoño

series ordinal

1

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language of work or name

English

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publication date

November 2004

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published in

Nature Reviews Cancer

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volume

4

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issue

11

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page(s)

876-90

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cites work

1 reference

Human and mouse proteases: a comparative genomic approach

21 January 2018

1 reference

ECM and cell surface proteolysis: regulating cellular ecology

21 January 2018

1 reference

The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19.

21 January 2018

1 reference

Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.

21 January 2018

1 reference

Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4

21 January 2018

1 reference

Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter

21 January 2018

1 reference

Tissue-specific expression of kallikrein family transgenes in mice and rats.

21 January 2018

1 reference

Ala217 is important for the catalytic function and autoactivation of prostate-specific human kallikrein 2.

21 January 2018

1 reference

Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors

21 January 2018

1 reference

Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2.

21 January 2018

1 reference

Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase

21 January 2018

1 reference

Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR

21 January 2018

1 reference

Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7

21 January 2018

1 reference

Characterization of the precursor of prostate-specific antigen. Activation by trypsin and by human glandular kallikrein.

21 January 2018

1 reference

Purification of human urinary prokallikrein. Identification of the site of activation by the metalloproteinase thermolysin

21 January 2018

1 reference

Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors

21 January 2018

1 reference

Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages

21 January 2018

1 reference

Human Kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related, but distinct, kallikreins in the prostate

21 January 2018

1 reference

Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation.

21 January 2018

1 reference

Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors

21 January 2018

1 reference

Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor

21 January 2018

1 reference

Phage display substrate: a blind method for determining protease specificity

21 January 2018

1 reference

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

21 January 2018

1 reference

Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology

21 January 2018

1 reference

Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer

21 January 2018

1 reference

Increased expression of protease M in ovarian tumors.

21 January 2018

1 reference

Human kallikrein 10: a novel tumor marker for ovarian carcinoma?

21 January 2018

1 reference

Prognostic value of the human kallikrein gene 15 expression in ovarian cancer

21 January 2018

1 reference

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

21 January 2018

1 reference

Predicting biomarkers for ovarian cancer using gene-expression microarrays

21 January 2018

1 reference

KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.

21 January 2018

1 reference

Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues

21 January 2018

1 reference

Kallikrein gene downregulation in breast cancer

21 January 2018

1 reference

Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues

21 January 2018

1 reference

Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues

21 January 2018

1 reference

Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues

21 January 2018

1 reference

Expression of the normal epithelial cell-specific 1 (NES1; KLK10) candidate tumour suppressor gene in normal and malignant testicular tissue

21 January 2018

1 reference

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

21 January 2018

1 reference

Concentration of enzymatically active prostate-specific antigen (PSA) in the extracellular fluid of primary human prostate cancers and human prostate cancer xenograft models

21 January 2018

1 reference

Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism

21 January 2018

1 reference

Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.

21 January 2018

1 reference

Testosterone and prostate specific antigen stimulate generation of reactive oxygen species in prostate cancer cells

21 January 2018

1 reference

Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.

21 January 2018

1 reference

Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues

21 January 2018

1 reference

Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer

21 January 2018

1 reference

TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

1 reference

Antiangiogenic activity of prostate-specific antigen

21 January 2018

1 reference

Prostate-specific antigen (PSA) protein does not affect growth of prostate cancer cells in vitro or prostate cancer xenografts in vivo

21 January 2018

1 reference

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein

21 January 2018

1 reference

Human prostate-specific antigen: structural and functional similarity with serine proteases

21 January 2018

1 reference

Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system

21 January 2018

1 reference

Activation of the 92 kDa type IV collagenase by tissue kallikrein

21 January 2018

1 reference

Regulation of 92-kDa Gelatinase B Activity in the Extracellular Matrix by Tissue Kallikrein

21 January 2018

1 reference

Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia

21 January 2018

1 reference

Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas

21 January 2018

1 reference

Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen

21 January 2018

1 reference

Recombinant prostate specific antigen inhibits angiogenesis in vitro and in vivo

21 January 2018

1 reference

Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma

21 January 2018

1 reference

A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness

21 January 2018

1 reference

Evidence that the prostate-specific antigen (PSA)/Zn2+ axis may play a role in human prostate cancer cell invasion

21 January 2018

1 reference

Role of thrombin receptor in breast cancer invasiveness

21 January 2018

1 reference

Prostate cancer cell adhesion to bone marrow endothelium: the role of prostate-specific antigen

21 January 2018

1 reference

Prostate-specific antigen induces osteoplastic changes by an autonomous mechanism.

21 January 2018

1 reference

Characterisation of human kallikrein 6/protease M expression in ovarian cancer

21 January 2018

1 reference

The promoter and the enhancer region of the KLK 3 (prostate specific antigen) gene is frequently mutated in breast tumours and in breast carcinoma cell lines

21 January 2018

1 reference

Breast cancer prognostic significance of a single nucleotide polymorphism in the proximal androgen response element of the prostate specific antigen gene promoter

21 January 2018

1 reference

The impact of polymorphism on prostate specific antigen gene on the risk, tumor volume and pathological stage of prostate cancer

21 January 2018

1 reference

Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels.

21 January 2018

1 reference

Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers

21 January 2018

1 reference

Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3.

21 January 2018

1 reference

Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates.

21 January 2018

1 reference

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

21 January 2018

1 reference

Liposome-mediated gene therapy using HSV-TK/ganciclovir under the control of human PSA promoter in prostate cancer cells

21 January 2018

1 reference

The new human kallikrein gene family: implications in carcinogenesis

21 January 2018

1 reference

The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers

21 January 2018

1 reference

cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes

21 January 2018

1 reference

Crystal structure of recombinant human tissue kallikrein at 2.0 A resolution

21 January 2018

1 reference

The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family

21 January 2018

1 reference

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

Role of loop structures of neuropsin in the activity of serine protease and regulated secretion

21 January 2018

1 reference

A genomic view of alternative splicing

21 January 2018

1 reference

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

21 January 2018

1 reference

Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer

21 January 2018

1 reference

Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer

21 January 2018

1 reference

A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate

21 January 2018

1 reference

Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues

21 January 2018

1 reference

Immunohistochemical localization of prostate-specific antigen in benign and malignant breast tissues

21 January 2018

1 reference

Expression of prostate-specific antigen (PSA) correlates with poor response to tamoxifen therapy in recurrent breast cancer

21 January 2018

1 reference

The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer.

21 January 2018

1 reference

Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance

21 January 2018

1 reference

Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer

21 January 2018

1 reference

Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis

21 January 2018

1 reference

The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer

21 January 2018

1 reference

The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer

21 January 2018

1 reference

Differential gene expression in ovarian carcinoma: identification of potential biomarkers

21 January 2018

1 reference

Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis

21 January 2018

1 reference

Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis

21 January 2018

1 reference

Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker

21 January 2018

1 reference

Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer

21 January 2018

1 reference

Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma

21 January 2018

1 reference

Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker

21 January 2018

1 reference

Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker

21 January 2018

1 reference

Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression

21 January 2018

1 reference

Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.

21 January 2018

1 reference

Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues

21 January 2018

1 reference

Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer

21 January 2018

1 reference

Quantitative analysis of kallikrein 15 gene expression in prostate tissue

21 January 2018

1 reference

Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA

21 January 2018

1 reference

Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma

21 January 2018

1 reference

Human Kallikrein 13: Production and Purification of Recombinant Protein and Monoclonal and Polyclonal Antibodies, and Development of a Sensitive and Specific Immunofluorometric Assay

21 January 2018

1 reference

Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue

21 January 2018

1 reference

Frequent detection of mutations in the 5' flanking region of the prostate-specific antigen gene in female breast cancer

21 January 2018

1 reference

Human Kallikrein 6 (hK6): A New Potential Serum Biomarker for Diagnosis and Prognosis of Ovarian Carcinoma

21 January 2018

1 reference

Original Articles: Prostate Cancer: Measurement of Serum Prostate Specific Antigen Levels in Women and in Prostatectomized Men With an Ultrasensitive Immunoassay Technique

21 January 2018

1 reference

Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer

21 January 2018

1 reference

alpha2-macroglobulin and C1-inactivator are plasma inhibitors of human glandular kallikrein

21 January 2018

1 reference

Substrate specificity of prostate-specific antigen (PSA)

31 March 2020

1 reference

A novel protease homolog differentially expressed in breast and ovarian cancer

31 March 2020

1 reference

The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells

31 March 2020

1 reference

Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue

31 March 2020

1 reference

Immunohistochemical distribution of the three predominant secretory proteins in the parenchyma of hyperplastic and neoplastic prostate glands

31 March 2020

1 reference

Tissue concentrations of prostate-specific antigen in prostatic carcinoma and benign prostatic hyperplasia

31 March 2020

1 reference

Evaluation of PAP and PSA gene expression in prostatic hyperplasia and prostatic carcinoma using northern-blot analyses, in situ hybridization and immunohistochemical stainings with monoclonal and bispecific antibodies

31 March 2020

1 reference

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

31 March 2020

1 reference

The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3-4, is downregulated by hypermethylation in acute lymphoblastic leukemia

31 March 2020

1 reference

Growth regulation of prostatic stromal cells by prostate-specific antigen

31 March 2020

1 reference

Prostatic kallikrein hK2, but not prostate-specific antigen (hK3), activates single-chain urokinase-type plasminogen activator

31 March 2020

1 reference

Mitogenic response of osteoblast cells to prostate-specific antigen suggests an activation of latent TGF-beta and a proteolytic modulation of cell adhesion receptors

31 March 2020

1 reference

Expression of tissue kallikrein and kinin receptors in angiogenic microvascular endothelial cells

31 March 2020

1 reference

Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen

31 March 2020

1 reference

Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese population

31 March 2020

1 reference

Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate

31 March 2020

1 reference

Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer

31 March 2020

1 reference

Substrate specificity of tissue kallikreins: importance of an extended interaction site

31 March 2020

1 reference

Identification of immunoreactive tissue kallikrein in human ductal breast carcinomas

31 March 2020

1 reference

Visualization of tissue kallikrein in human breast carcinoma by two-dimensional western blotting and immunohistochemistry

31 March 2020

1 reference

Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma

31 March 2020

1 reference

Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer

31 March 2020

1 reference

Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera

31 March 2020

1 reference

Tissue kallikrein effectively activates latent matrix degrading metalloenzymes

31 March 2020

1 reference

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Identifiers

DOI

10.1038/NRC1474

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

282858

1018810023

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282858

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference