TGF-beta signaling in tumor suppression and cancer progression (Q29615427)

Europe PubMed Central

title

TGF-beta signaling in tumor suppression and cancer progression (English)

1 reference

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30 April 2017

author name string

Derynck R

series ordinal

1

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30 April 2017

Akhurst RJ

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11586292

30 April 2017

Balmain A

series ordinal

3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11586292

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11586292

30 April 2017

language of work or name

1 reference

30 April 2017

publication date

October 2001

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30 April 2017

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30 April 2017

volume

29

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issue

2

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30 April 2017

page(s)

117-29

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https://scigraph.springernature.com/pub.10.1038/ng1001-117

30 April 2017

exact match

0 references

cites work

TGF-beta signal transduction

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Latent transforming growth factor-beta: structural features and mechanisms of activation

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The latent transforming growth factor beta binding protein (LTBP) family

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Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

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7 January 2021

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

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7 January 2021

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

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7 January 2021

The urokinase-type plasminogen activator system in cancer metastasis: a review

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7 January 2021

Matrix metalloproteinases in tumor invasion and metastasis

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7 January 2021

Proteases in invasion: matrix metalloproteinases

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7 January 2021

Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism

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7 January 2021

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

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7 January 2021

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

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7 January 2021

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

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7 January 2021

Signaling of transforming growth factor-beta family members through Smad proteins

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

How cells read TGF-beta signals

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7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta signaling by Smad proteins

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mechanism of TGFbeta receptor inhibition by FKBP12

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

FKBP12 is a negative regulator of transforming growth factor-beta receptor internalization

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smads: transcriptional activators of TGF-beta responses

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smads bind directly to the Jun family of AP-1 transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Regulation of Smad signalling by protein associations and signalling crosstalk

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Signaling inputs converge on nuclear effectors in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Requirements for transforming growth factor-beta regulation of the pro-alpha 2(I) collagen and plasminogen activator inhibitor-1 promoters

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Potentiation of Smad transactivation by Jun proteins during a combined treatment with epidermal growth factor and transforming growth factor-beta in rat hepatocytes. role of phosphatidylinositol 3-kinase-induced AP-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c-fos or c-jun

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Characterization of the mouse transforming growth factor-beta 1 promoter and activation by the Ha-ras oncogene

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Altered regulation of TGF-beta 1 and TGF-alpha in primary keratinocytes and papillomas expressing v-Ha-ras

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Role of Ras and Mapks in TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

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https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Repression of p15INK4b expression by Myc through association with Miz-1

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad7 inhibits the survival nuclear factor kappaB and potentiates apoptosis in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Activation of caspase-8 in transforming growth factor-beta-induced apoptosis of human hepatoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mutations of the transforming growth factor beta type II receptor gene and microsatellite instability in gastric cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mutation analysis of the transforming growth factor beta type II receptor in sporadic human cancers of the pancreas, liver, and breast.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Gene mutation of transforming growth factor beta1 type II receptor in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Analyses of microsatellite instability and the transforming growth factor-beta receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

https://api.crossref.org/works/10.1038%2FNG1001-117

1 reference

7 January 2021

A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-beta1) type I and type II receptors in human prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Consistent loss of functional transforming growth factor beta receptor expression in murine plasmacytomas

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-beta and other growth inhibitory cytokines: evidence for multiple growth inhibitory signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Overexpression of transforming growth factor beta-type II receptor reduces tumorigenicity and metastastic potential of K-ras-transformed thyroid cells.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Alteration of cell growth and morphology by overexpression of transforming growth factor beta type II receptor in human lung adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Somatic alterations of the SMAD-2 gene in human colorectal cancers

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-beta signals

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mechanism for mutational inactivation of the tumor suppressor Smad2.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Expression of the c-ski proto-oncogene in human melanoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

M6P/IGF2R is mutated in squamous cell carcinoma of the lung

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Epithelial cell plasticity in development and tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Spindle cell carcinoma.Ultrastructural evidence of squamous origin and collagen production by the tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor-beta 3 is required for secondary palate fusion

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Vertebrate mesendoderm induction and patterning

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Effects of transforming growth factor beta on growth of human mammary epithelial cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Autocrine TGF-beta-regulated expression of adhesion receptors and integrin-linked kinase in HT-144 melanoma cells correlates with their metastatic phenotype

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Cyclosporine induces cancer progression by a cell-autonomous mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Basic fibroblast growth factor and transforming growth factor beta-1: synergistic mediators of angiogenesis in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Defective angiogenesis in mice lacking endoglin

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Positive correlation of plasma transforming growth factor-beta 1 levels with tumor vascularity in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Elevated plasma levels of TGF-beta 1 in patients with invasive prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta 1 is significantly elevated in plasma of patients suffering from renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Macrophage-derived angiogenesis factors

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Bidirectional regulation of macrophage function by TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Regulation of immune responses by TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transfection of transforming growth factor-beta producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

The immunoregulatory effects of NK cells: the role of TGF-beta and implications for autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Reversal of tamoxifen resistance of human breast carcinomas in vivo by neutralizing antibodies to transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Regulation of the proinflammatory effects of Fas ligand (CD95L).

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Immunosuppressive factors: role in cancer development and progression

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Transforming growth factor beta 1 is implicated in the failure of tamoxifen therapy in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Blockade of transforming growth factor-beta signaling does not abrogate antiestrogen-induced growth inhibition of human breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Suppression of TGF-beta1 in human gliomas by retroviral gene transfection enhances susceptibility to LAK cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Negative regulation of transforming growth factor-beta by the proteoglycan decorin

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor beta antibody and interleukin-2

1 reference

https://api.crossref.org/works/10.1038%2FNG1001-117

7 January 2021

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11586292

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

247603

Dimensions Publication ID

1010058562

0 references

OpenCitations bibliographic resource ID

247603

1 reference