Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study (Q28290823)

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English	Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study	scientific article

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scholarly article

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Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study (English)

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relapsing-remitting multiple sclerosis

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multiple sclerosis

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Cris Constantinescu

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object named as

Cris S Constantinescu

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author name string

Benjamin M Segal

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Aparna Raychaudhuri

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Lilianne Kim

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Rosanne Fidelus-Gort

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Lloyd H Kasper

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language of work or name

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publication date

September 2008

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Lancet Neurology

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7

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796-804

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Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions

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Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

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Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.

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Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand

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IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

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Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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IL-12 dependent/IFN gamma independent expression of CCR5 by myelin-reactive T cells correlates with encephalitogenicity

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1 reference

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1 reference

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1 reference

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10.1016/S1474-4422(08)70173-X

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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