Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) (Q28280453)

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English	Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)	scientific article

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7 January 2020

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) (English)

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7 January 2020

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placebo-controlled trial

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monoclonal antibody

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Alexandra Boer Kimball

2

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Kim A Papp

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Craig L Leonardi

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Newman Yeilding

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Cynthia Guzzo

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Yuhua Wang

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Shu Li

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7 January 2020

Lisa T Dooley

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7 January 2020

Kenneth B Gordon

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7 January 2020

PHOENIX 1 study investigators

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1 May 2008

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7 January 2020

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1665-1674

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What have we learned in dermatology from the biologic therapies?

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Biological therapies in the systemic management of psoriasis: International Consensus Conference

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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

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Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

1 reference

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In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

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Interleukin-12, interleukin-23, and psoriasis: current prospects

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A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

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Severe Psoriasis – Oral Therapy with a New Retinoid

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IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human.

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Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

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The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis

1 reference

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10.1016/S0140-6736(08)60725-4

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Europe PubMed Central

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7 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18486739%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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