Cell-cycle checkpoints and cancer (Q28293996)

cell cycle checkpoint signaling

Europe PubMed Central

title

Cell-cycle checkpoints and cancer (English)

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main subject

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2

Jiri Bartek

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author name string

Michael B Kastan

series ordinal

1

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language of work or name

English

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publication date

18 November 2004

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published in

Nature

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volume

432

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page(s)

316-23

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issue

7015

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cites work

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Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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Regulating mammalian checkpoints through Cdc25 inactivation

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

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Interaction of FANCD2 and NBS1 in the DNA damage response

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

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Cancer susceptibility and the functions of BRCA1 and BRCA2

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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Biallelic inactivation of BRCA2 in Fanconi anemia

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The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

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Checkpoints: controls that ensure the order of cell cycle events

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Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

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ATM: genome stability, neuronal development, and cancer cross paths

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

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Requirement of the MRN complex for ATM activation by DNA damage

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

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53BP1, an activator of ATM in response to DNA damage

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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Checking on the fork: the DNA-replication stress-response pathway

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Opening of the clamp: an intimate view of an ATP-driven biological machine.

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ATR and ATM regulate the timing of DNA replication origin firing

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Hypoxia links ATR and p53 through replication arrest

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Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

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7 January 2021

Chk1 and Chk2 kinases in checkpoint control and cancer

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7 January 2021

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

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7 January 2021

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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7 January 2021

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

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7 January 2021

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

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7 January 2021

53BP1, a mediator of the DNA damage checkpoint

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7 January 2021

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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7 January 2021

The cellular response to DNA double-strand breaks: defining the sensors and mediators

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7 January 2021

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

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7 January 2021

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

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7 January 2021

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

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7 January 2021

The retinoblastoma protein pathway in cell cycle control and cancer

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The RB and p53 pathways in cancer

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7 January 2021

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

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7 January 2021

Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.

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7 January 2021

Checking on DNA damage in S phase

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7 January 2021

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

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7 January 2021

The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

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7 January 2021

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

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7 January 2021

Toward maintaining the genome: DNA damage and replication checkpoints

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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7 January 2021

Regulation of the G2/M transition by p53.

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients.

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7 January 2021

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Checkpoint mediators: relaying signals from DNA strand breaks

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

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7 January 2021

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Collaboration of Brca1 and Chk2 in tumorigenesis

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

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7 January 2021

The Fanconi road to cancer

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

Identifiers

DOI

10.1038/NATURE03097

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

569790

1012054610

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569790

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference