Regulation of the G2/M transition by p53. (Q33943437)

30 July 2017

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title

Regulation of the G2/M transition by p53. (English)

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30 July 2017

W R Taylor

1

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30 July 2017

G R Stark

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 April 2001

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30 July 2017

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30 July 2017

20

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30 July 2017

1803-1815

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30 July 2017

15

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204252

30 July 2017

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cites work

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Caffeine inhibits the checkpoint kinase ATM

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Diverse molecular interactions of the hnRNP K protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Cdc25 protein phosphatases in cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Association of p300 and CBP with simian virus 40 large T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 regulation of G(2) checkpoint is retinoblastoma protein dependent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Abnormal centrosome amplification in the absence of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Okadaic acid overrides the S-phase check point and accelerates progression of G2-phase to induce premature mitosis in HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

MPF localization is controlled by nuclear export

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Inhibition of cyclin-dependent kinases by p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Checkpoints: controls that ensure the order of cell cycle events

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p21Waf1 inhibits the activity of cyclin dependent kinase 2 by preventing its activating phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Genomic instability in Gadd45a-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 regulates a G2 checkpoint through cyclin B1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Regulation of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Identification of CIP-1-associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Heterogeneous nuclear ribonucleoprotein K is a transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Universal control mechanism regulating onset of M-phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The G(2) checkpoint is maintained by redundant pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Cyclins and cyclin-dependent kinases: a biochemical view

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 regulates the minimal promoter of the human topoisomerase IIalpha gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Regulation of CAK kinase activity by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Role of wild type p53 in the G2 phase: regulation of the gamma-irradiation-induced delay and DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p21 Inhibits Thr161Phosphorylation of Cdc2 to Enforce the G2DNA Damage Checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The molecular basis and clinical management of ataxia telangiectasia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Identification of a cell-type-specific and E2F-independent mechanism for repression of cdc2 transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 inhibits entry into mitosis when DNA synthesis is blocked

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Mechanisms of G2 arrest in response to overexpression of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p130/E2F4 binds to and represses the cdc2 promoter in response to p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

CDC5 and CKII control adaptation to the yeast DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

A novel p53-inducible gene coding for a microtubule-localized protein with G2-phase-specific expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

GADD45 induction of a G2/M cell cycle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Target gene specificity of E2F and pocket protein family members in living cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2 arrest in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Biochemical Differences between Staurosporine-Induced Apoptosis and Premature Mitosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204252

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204252

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference