Netrin-1 and its receptors in tumorigenesis (Q28295909)

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Europe PubMed Central

title

Netrin-1 and its receptors in tumorigenesis (English)

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1

Hirofumi Arakawa

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language of work or name

English

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publication date

December 2004

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published in

Nature Reviews Cancer

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volume

4

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issue

12

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page(s)

978-87

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cites work

1 reference

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

21 April 2017

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The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

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Quantification of expression of netrins, slits and their receptors in human prostate tumors

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Mad-related genes in the human

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Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

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The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

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Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns

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Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

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Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers

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Homozygous deletions at 3p12 in breast and lung cancer

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Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity

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The dependence receptor hypothesis

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The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

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Mediation of the DCC apoptotic signal by DIP13 alpha

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UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE

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Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

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Akt signaling: linking membrane events to life and death decisions

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p53RDL1 regulates p53-dependent apoptosis

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A genetic model for colorectal tumorigenesis

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Identification of semaphorin3B as a direct target of p53

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IAP proteins: blocking the road to death's door

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The molecular biology of axon guidance

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Dynamic regulation of axon guidance.

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DCC: is there a connection between tumorigenesis and cell guidance molecules?

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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

21 January 2018

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The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

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UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans

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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

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UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

21 January 2018

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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

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Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

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Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer

21 January 2018

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Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder

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Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer

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Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

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Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration

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Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines

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Tumor suppressors on 3p: a neoclassic quartet

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Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer

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Scatter-factor and semaphorin receptors: cell signalling for invasive growth

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To move or not to move? Semaphorin signalling in cell migration

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Apoptosis and dependence receptors: a molecular basis for cellular addiction

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Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

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Dependence receptors: between life and death.

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A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

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B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

21 January 2018

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The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.

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Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

21 January 2018

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Identification of a chromosome 18q gene that is altered in colorectal cancers

21 January 2018

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Putative cancer gene shows up in development instead

31 March 2020

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The DCC gene product in cellular differentiation and colorectal tumorigenesis

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Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

31 March 2020

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Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers

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Genetic alterations in localized prostate cancer: Identification of a common region of deletion on chromosome arm 18q

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Expression of the DCC gene in myelodysplastic syndromes and overt leukemia

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Semaphorin-3F is an inhibitor of tumor angiogenesis

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Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family

31 March 2020

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The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells

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Receptor links blood vessels, axons

31 March 2020

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Slit-Robo: neuronal guides signal in tumor angiogenesis

31 March 2020

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Dimerization-dependent block of the proapoptotic effect of p75(NTR)

31 March 2020

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Genetic alterations during colorectal-tumor development

31 March 2020

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Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected].

31 March 2020

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