Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action (Q28298376)

1

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Edgar Zitron

2

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Sonja Lück

3

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Ramona Bloehs

4

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Eberhard P Scholz

5

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Sven Kathöfer

6

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Dierk Thomas

7

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Volker A W Kreye

8

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Wolfgang Schoels

10

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Christoph A Karle

11

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Johann Kiehn

Naunyn-Schmiedeberg's Archives of Pharmacology

12

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language of work or name

English

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publication date

December 2004

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published in

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volume

370

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issue

6

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page(s)

423-35

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cites work

Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts

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Crossref

https://api.crossref.org/works/10.1007%2FS00210-004-0976-8

Proposed diagnostic criteria for the Brugada syndrome

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS00210-004-0976-8

Ajmaline-induced torsade de pointes

21 January 2018

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12 December 2020

A structural basis for drug-induced long QT syndrome

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12 December 2020

Molecular determinants of dofetilide block of HERG K+ channels

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12 December 2020

Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block

1 reference

12 December 2020

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels

1 reference

12 December 2020

Efficacy of ajmaline and propafenone in patients with accessory pathways: a prospective randomized study

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12 December 2020

Comparison of exercise and ajmaline tests with electrophysiologic study in the Wolff-Parkinson-White syndrome

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12 December 2020

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12 December 2020

Comparison of antiarrhythmic effects of oral prajmalium bitartrate and intravenous lidocaine in acute myocardial infarction

1 reference

12 December 2020

Torsade de pointes induced by ajmaline.

1 reference

12 December 2020

Bertosamil blocks HERG potassium channels in their open and inactivated states

1 reference

12 December 2020

Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine

1 reference

12 December 2020

Acute ajmaline poisoning. Study of 7 cases

1 reference

12 December 2020

Ajmaline in WPW syndrome: an electrophysiologic study

1 reference

12 December 2020

Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel

1 reference

12 December 2020

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide

1 reference

12 December 2020

Effects of ajmaline on non-sodium ionic currents in guinea pig ventricular myocytes.

1 reference

12 December 2020

Pharmacokinetics and antiarrhythmic efficacy of intravenous ajmaline in ventricular arrhythmia of acute onset

1 reference

12 December 2020

Differential effects of alkaloids on sodium currents of isolated single skeletal muscle fibers

1 reference

12 December 2020

Pharmacokinetics and electrophysiological effects of intravenous ajmaline

1 reference

12 December 2020

Follicular tissues reduce drug effects on ion channels in oocytes of Xenopus laevis

1 reference

12 December 2020

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

1 reference

12 December 2020

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

1 reference

12 December 2020

Physicochemical features of the HERG channel drug binding site

1 reference

12 December 2020

Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels

1 reference

12 December 2020

What to do in patients with no structural heart disease and sudden arrhythmic death?

1 reference

12 December 2020

Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

1 reference

12 December 2020

Torsade de pointes after mesocaine and ajmaline in a patient with intermittent atrioventricular block. Favorable therapeutic effect of high doses of isoprenaline

1 reference

12 December 2020

Pathways of HERG inactivation

1 reference

12 December 2020

High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.

1 reference

12 December 2020

Effect of procaine amide, quinidine, and ajmaline in the Wolff-Parkinson-White syndrome

1 reference

12 December 2020

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

1 reference

12 December 2020

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

12 December 2020

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

1 reference

12 December 2020

Voltage-Dependent Profile of HumanEther-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain

1 reference

12 December 2020

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

1 reference

12 December 2020

Proarrhythmic effect of ajmaline in idiopathic ventricular tachycardia

1 reference

12 December 2020

Electrophysiological and haemodynamic effects of lidocaine and ajmaline in the management of sustained ventricular tachycardia

1 reference

12 December 2020

10.1007/S00210-004-0976-8

Identifiers

DOI

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Dimensions Publication ID

1021688250

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Fatcat ID

release_wnxccxwrnnhxrfq5fddm6la4sy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wnxccxwrnnhxrfq5fddm6la4sy

24 November 2022