Physicochemical features of the HERG channel drug binding site (Q44709094)

5 December 2017

title

Physicochemical features of the HERG channel drug binding site (English)

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5 December 2017

David Fernandez

1

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5 December 2017

Azad Ghanta

series ordinal

2

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5 December 2017

Gregory W Kauffman

series ordinal

3

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5 December 2017

Michael C Sanguinetti

series ordinal

4

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5 December 2017

language of work or name

English

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publication date

29 December 2003

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Journal of Biological Chemistry

5 December 2017

published in

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5 December 2017

volume

279

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5 December 2017

issue

11

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5 December 2017

page(s)

10120-10127

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Molecular and cellular mechanisms of cardiac arrhythmias

5 December 2017

cites work

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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

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Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior

21 January 2018

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

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HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

21 January 2018

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

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The impact of drug-induced QT interval prolongation on drug discovery and development

21 January 2018

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Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

21 January 2018

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A structural basis for drug-induced long QT syndrome

21 January 2018

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Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block

21 January 2018

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Voltage-Dependent Profile of HumanEther-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain

21 January 2018

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Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

21 January 2018

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Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes

21 January 2018

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Electrophysiological recording from Xenopus oocytes

21 January 2018

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Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

21 January 2018

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HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

21 January 2018

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Prediction of Physicochemical Parameters by Atomic Contributions

21 January 2018

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 January 2018

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

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The open pore conformation of potassium channels

21 January 2018

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Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

21 January 2018

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Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

21 January 2018

1 reference

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Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamine

21 January 2018

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Interior and surface of monomeric proteins

21 January 2018

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21 January 2018

Hydrophobicity regained.

1 reference

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Comparing the polarities of the amino acids: side-chain distribution coefficients between the vapor phase, cyclohexane, 1-octanol, and neutral aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310683200

21 January 2018

Identifiers

DOI

10.1074/JBC.M310683200

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5 December 2017

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