Signalling pathways and molecular interactions of NOD1 and NOD2 (Q28298636)

Nature Reviews Immunology

Europe PubMed Central

title

Signalling pathways and molecular interactions of NOD1 and NOD2 (English)

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main subject

molecular interaction

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Warren Strober

1

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Peter J Murray

series ordinal

2

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Atsushi Kitani

series ordinal

3

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Tomohiro Watanabe

series ordinal

4

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language of work or name

English

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publication date

January 2006

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published in

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volume

6

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issue

1

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page(s)

9-20

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cites work

Toll-like receptor signalling

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NODs: intracellular proteins involved in inflammation and apoptosis

31 March 2020

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

31 March 2020

1 reference

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

31 March 2020

1 reference

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

31 March 2020

1 reference

NOD1 variation, immunoglobulin E and asthma.

31 March 2020

1 reference

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

31 March 2020

1 reference

CATERPILLER: a novel gene family important in immunity, cell death, and diseases

31 March 2020

1 reference

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

31 March 2020

1 reference

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

31 March 2020

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Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

31 March 2020

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

31 March 2020

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

31 March 2020

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Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

31 March 2020

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

31 March 2020

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Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

31 March 2020

1 reference

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

31 March 2020

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CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

31 March 2020

1 reference

Crohn's disease and the NOD2 gene: a role for paneth cells

31 March 2020

1 reference

Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells

31 March 2020

1 reference

Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors

31 March 2020

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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

31 March 2020

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TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

31 March 2020

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IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism

31 March 2020

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NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

31 March 2020

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Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

31 March 2020

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Comparison of biosynthesis and subcellular distribution of lysozyme and lysosomal enzymes in U937 monocytes.

31 March 2020

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Isolation of glucosaminyl-beta(1-4)-muramic acid and phosphoric acid ester of this disaccharide from acid hydrolysates of peptidoglycan of Bacillus cereus AHU 1356 cell walls

31 March 2020

1 reference

hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

31 March 2020

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Leucine-rich repeats and pathogen recognition in Toll-like receptors.

31 March 2020

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Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

31 March 2020

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Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

31 March 2020

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Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

31 March 2020

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

31 March 2020

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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

31 March 2020

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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

31 March 2020

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The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

31 March 2020

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

31 March 2020

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GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

31 March 2020

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

31 March 2020

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CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

31 March 2020

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Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses

31 March 2020

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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

31 March 2020

1 reference

CLAN, a novel human CED-4-like gene

31 March 2020

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Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response

31 March 2020

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

31 March 2020

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CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways

31 March 2020

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Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

31 March 2020

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c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

31 March 2020

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Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

31 March 2020

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How NOD-ing off leads to Crohn disease

31 March 2020

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

31 March 2020

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Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

31 March 2020

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Staphylococcus aureus peptidoglycan is a toll-like receptor 2 activator: a reevaluation

31 March 2020

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Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

31 March 2020

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The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan

31 March 2020

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Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

31 March 2020

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Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release

31 March 2020

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

31 March 2020

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Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

31 March 2020

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Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

31 March 2020

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Synergistic enhancement of Toll-like receptor responses by NOD1 activation

31 March 2020

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TLR signaling in the gut in health and disease

31 March 2020

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Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide

31 March 2020

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TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells

31 March 2020

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Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.

31 March 2020

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Negative regulation of toll-like receptor-mediated signaling by Tollip

31 March 2020

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

31 March 2020

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Epithelial cells pay a Toll for protection

31 March 2020

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Commensal host-bacterial relationships in the gut

31 March 2020

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CARD15 mutations in Blau syndrome

31 March 2020

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Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome

31 March 2020

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Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

31 March 2020

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Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

31 March 2020

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Interactions between commensal intestinal bacteria and the immune system

31 March 2020

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Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

31 March 2020

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NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

31 March 2020

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Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria

31 March 2020

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Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

31 March 2020

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NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

31 March 2020

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Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice

31 March 2020

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Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense

31 March 2020

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Mucosal flora in inflammatory bowel disease

31 March 2020

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Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer

31 March 2020

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High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

31 March 2020

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Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

31 March 2020

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Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

31 March 2020

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Helicobacter pylori infection and the development of gastric cancer

31 March 2020

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Genetic variation in DLG5 is associated with inflammatory bowel disease

31 March 2020

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The immunological and genetic basis of inflammatory bowel disease

31 March 2020

1 reference

The immunology of mucosal models of inflammation

31 March 2020

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Bacterial flagellin is a dominant antigen in Crohn disease.

31 March 2020

1 reference

Insights into the mechanism of oral tolerance derived from the study of models of mucosal inflammation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1747

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Consolidated OpenCitations Corpus – April 2017

2962719

2962719

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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