Cytokines in the pathogenesis of rheumatoid arthritis (Q28303865)

Nature Reviews Immunology

Europe PubMed Central

title

Cytokines in the pathogenesis of rheumatoid arthritis (English)

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Iain B McInnes

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Georg Schett

series ordinal

2

object named as

Georg Schett

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language of work or name

English

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publication date

June 2007

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published in

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volume

7

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page(s)

429-42

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issue

6

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cites work

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Even though T-cell-directed trials have been of limited success, is there reason for optimism?

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The balance of Th1/Th2 cytokines in rheumatoid arthritis

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The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

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Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

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T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.

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Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood

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Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

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Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27.

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

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Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

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The role of the T cell in autoimmune inflammation

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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

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Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta

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T-cell-targeted therapies in rheumatoid arthritis

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Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis

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CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis

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Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium

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Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88

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The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis

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Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twe

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Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling

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A proinflammatory role for IL-18 in rheumatoid arthritis

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Interleukin-18: a therapeutic target in rheumatoid arthritis?

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IL-32, a proinflammatory cytokine in rheumatoid arthritis

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IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism

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High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis

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MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

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Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis

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The Mast Cell in Inflammatory Arthritis

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Mast cells: a cellular link between autoantibodies and inflammatory arthritis

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A subset of natural killer cells is greatly expanded within inflamed joints

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The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis

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High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study

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High-sensitivity C-reactive protein and fracture risk in elderly women

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Inflammatory Mediators as Essential Elements in Bone Remodeling

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Bone resorption by osteoclasts

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Osteoclasts are essential for TNF-alpha-mediated joint destruction

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Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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Constitutive mRNA and protein production of macrophage colony-stimulating factor but not of other cytokines by synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

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Expression of osteoclast differentiation factor in rheumatoid arthritis

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

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RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.

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Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

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T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

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Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation

31 March 2020

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Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors.

31 March 2020

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Dickkopf-1 is a master regulator of joint remodeling

31 March 2020

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The role of mesenchymal cells in the pathophysiology of inflammatory arthritis

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Cadherin-11 in synovial lining formation and pathology in arthritis

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Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis

31 March 2020

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Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism

31 March 2020

1 reference

Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis?

31 March 2020

1 reference

Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated prot

31 March 2020

1 reference

Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism

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1 reference

Lessons from animal models of arthritis

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Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint

31 March 2020

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Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction

31 March 2020

1 reference

Effect of interleukin 17 on proteoglycan degradation in murine knee joints

31 March 2020

1 reference

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

31 March 2020

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Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo

31 March 2020

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Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting.

31 March 2020

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Angiogenesis in rheumatoid arthritis

31 March 2020

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CCR5 is characteristic of Th1 lymphocytes

31 March 2020

1 reference

Chemokine blockade: a new era in the treatment of rheumatoid arthritis?

31 March 2020

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Chemokines and their receptors in rheumatoid arthritis: future targets?

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1 reference

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial

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31 March 2020

Identifiers

DOI

10.1038/NRI2094

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Consolidated OpenCitations Corpus – April 2017

release_mc6vpoldvzgjjbezdnuauktumm

140596

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/mc6vpoldvzgjjbezdnuauktumm

mapped directly with Wikidata item

24 November 2022

based on heuristic

140596

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference