Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine (Q28326901)

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organophosphonate

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author name string

S. A. Foster

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J. Cerny

2

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Y. C. Cheng

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full work available at URL

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language of work or name

English

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publication date

5 January 1991

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http://intl.jbc.org/cgi/content/abstract/266/1/238

online access status

open access

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Journal of Biological Chemistry

8 December 2022

published in

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volume

266

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page(s)

238-44

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issue

1

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cites work

Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues

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Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

8 December 2022

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Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

8 December 2022

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Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo

8 December 2022

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Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication

8 December 2022

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Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

8 December 2022

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Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

8 December 2022

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9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections

8 December 2022

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Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant

8 December 2022

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Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus

8 December 2022

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Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1

8 December 2022

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Cloning of herpes simplex virus type 1 sequences representing the whole genome

8 December 2022

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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

8 December 2022

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Action of pancreatic DNase: requirements for activation of DNA as a template-primer for DNA polymerase ∝

8 December 2022

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

8 December 2022

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The detection of DNA-binding proteins by protein blotting

8 December 2022

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Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition

8 December 2022

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Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin

8 December 2022

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Mode of action of phosphonoformate as an anti-herpes simplex virus agent

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Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.

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Identifiers