Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins (Q28343598)

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Language	Label	Description	Also known as
English	Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins	scientific article

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Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins (English)

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1 reference

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author name string

H Ma

1

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T M Penning

2

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language of work or name

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publication date

28 September 1999

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Proceedings of the National Academy of Sciences of the United States of America

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96

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20

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11161-6

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Atomic structure of progesterone complexed with its receptor

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Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution

1 reference

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Molecular basis of agonism and antagonism in the oestrogen receptor

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Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

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The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

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Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+

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Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily

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Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids

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Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.

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1 reference

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Partial characterization of the cytosol 3α-hydroxysteroid:NAD(P)+oxidoreductase of rat ventral prostate

1 reference

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Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase

1 reference

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Molecular endocrinology of hydroxysteroid dehydrogenases

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The rat 17α-hydroxylase-17,20-desmolase (CYP17) active site: Computerized homology modeling and site directed mutagenesis

1 reference

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The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

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A new nomenclature for the aldo-keto reductase superfamily

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Expression and Characterization of Recombinant Type 2 3 -Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3 /17 -HSD Activity and Cellular Distribution

1 reference

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Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile

1 reference

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The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase

1 reference

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12 December 2020

based on heuristic

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Stereochemistry of hydrogen transfer by rat ovary 20 alpha-hydroxysteroid dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10500147

12 December 2020

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Kinetic studies of rat ovarian 20 alpha-hydroxysteroid dehydrogenase

1 reference

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A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework

1 reference

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based on heuristic

inferred from PubMed ID database lookup

The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence

1 reference

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The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme

1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.96.20.11161

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1999PNAS...9611161M

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release_krhqy3vv3zcvdpufnfuk3rusg4

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PMC publication ID

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