The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats (Q28344876)

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English	The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats	scientific article

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The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats (English)

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author name string

Annis O Mechan

1

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Blanca Esteban

2

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Esther O'Shea

3

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J Martin Elliott

4

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M Isabel Colado

5

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A Richard Green

6

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publication date

January 2002

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British Journal of Pharmacology

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135

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1

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170-80

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The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain

1 reference

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20 March 2017

Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine

1 reference

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20 March 2017

5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

1 reference

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20 March 2017

Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

1 reference

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29 September 2017

MDMA induced hyperthermia: a survivor with an initial body temperature of 42.9 degrees C.

1 reference

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29 September 2017

Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine.

1 reference

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29 September 2017

Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats

1 reference

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29 September 2017

The hyperthermic and neurotoxic effects of ‘Ecstasy’ (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype

1 reference

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29 September 2017

Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor

1 reference

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29 September 2017

Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan

1 reference

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29 September 2017

Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants: II.

1 reference

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29 September 2017

Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1 reference

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29 September 2017

5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine

1 reference

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29 September 2017

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

29 September 2017

Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

29 September 2017

The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.

1 reference

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2 June 2018

Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux

1 reference

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2 June 2018

A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds

1 reference

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2 June 2018

Dopaminergic and serotonergic mechanisms of thermoregulation: mediation of thermal effects of apomorphine and dopamine

1 reference

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2 June 2018

Role of the serotonin uptake carrier in the neurochemical response to methamphetamine: effects of citalopram and chlorimipramine

1 reference

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2 June 2018

Stereoselective N-oxygenation of zimeldine and homozimeldine by the flavin-containing monooxygenase

1 reference

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2 June 2018

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat.

1 reference

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2 June 2018

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1 reference

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2 June 2018

Role of the dopamine uptake carrier in the neurochemical response to methamphetamine: effects of amfonelic acid

1 reference

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2 June 2018

A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors

1 reference

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2 June 2018

The effects of monoamine uptake inhibitors and methamphetamine on neostriatal 6-hydroxydopamine (6-OHDA) formation, short-term monoamine depletions and locomotor activity in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine

1 reference

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2 June 2018

Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes

1 reference

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2 June 2018

Ecstasy and dantrolene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Ecstasy and the dance of death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

2 June 2018

A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

Caveat emptor: editors beware

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

Ecstasy and dantrolene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573106

27 November 2018

'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of selective dopamine receptor agonists and antagonists on body temperature in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by in vivo microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction between the central and peripheral nervous systems in mediating the thermic effect of methamphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MDMA induced dopamine release in vivo: role of endogenous serotonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasodilation and body warming in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for an alpha-1 receptor-mediated central sympathoinhibitory action of ketanserin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sulpiride and SCH 23390 on methamphetamine-induced changes in body temperature and lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/11786492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/SJ.BJP.0704442

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