Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis (Q28344948)

2

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G Boigk

3

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M Bauer

4

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E G Hahn

5

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E-O Riecken

6

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D Schuppan

Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney

7

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language of work or name

English

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publication date

February 2002

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published in

Gut

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volume

50

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page(s)

241-7

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issue

2

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cites work

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Inhibition by xanthine derivatives of adenosine receptor-stimulated cyclic adenosine 3′, 5′-monophosphate accumulation in rat and guinea-pig thymocytes

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein

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Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

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Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

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Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts

7 April 2017

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Expression of connective tissue growth factor in experimental rat and human liver fibrosis

29 September 2017

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Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis

29 September 2017

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A major role for matrix metalloproteinases in T cell injury in the gut.

29 September 2017

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Pentoxifylline for the treatment of HIV infection and its complications

29 September 2017

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Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies

29 September 2017

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Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

29 September 2017

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Serum assays for liver fibrosis.

29 September 2017

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Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy

29 September 2017

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Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene

29 September 2017

1 reference

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Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis

29 September 2017

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cDNA cloning by PCR of rat transforming growth factor beta-1.

29 September 2017

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Experimental models of hepatic fibrosis: a review

29 September 2017

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Identification of a gene family regulated by transforming growth factor-beta

29 September 2017

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29 September 2017

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Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta 1.

2 June 2018

1 reference

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Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity.

2 June 2018

1 reference

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Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats

2 June 2018

1 reference

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Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells

2 June 2018

1 reference

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Elevated serum aminoterminal procollagen type-III-peptide parallels collagen accumulation in rats with secondary biliary fibrosis

2 June 2018

1 reference

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Construction of DNA sequences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D.

2 June 2018

1 reference

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Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Serum concentration of the aminoterminal procollagen type III peptide in the rat reflects early formation of connective tissue in experimental liver cirrhosis.

2 June 2018

1 reference

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A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta

2 June 2018

1 reference

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The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Effect of pentoxifylline on liver plasma flow in normal man

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat.

27 November 2018

1 reference

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Inhibition of collagen lattice contraction by pentoxifylline and interferon-alpha, -beta, and -gamma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Pentoxifylline inhibits production of superoxide anion and tumor necrosis factor by Kupffer cells in rat liver preservation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1773098

Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor

27 November 2018

1 reference

12 December 2020

The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts

1 reference

12 December 2020

The effect of pentoxifylline on liver perfusion: a comparative study in patients with liver diseases and in normal subjects, using 198Au-colloid-scintigraphy (author's transl)

1 reference

12 December 2020

A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues

1 reference

12 December 2020

Suppression of experimental hepatic fibrosis by administration of vitamin A

1 reference

12 December 2020

Chemotherapeutic potential of phosphodiesterase inhibitors

1 reference

12 December 2020

Molecular regulation of hepatic fibrogenesis

1 reference

12 December 2020

Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells

1 reference

12 December 2020

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP

1 reference

12 December 2020

Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells

1 reference

12 December 2020

Pentoxifylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema

1 reference

12 December 2020

Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation

1 reference

12 December 2020

Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors

1 reference

12 December 2020

Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat

1 reference

12 December 2020

Effect of pentoxifylline on the fibrogenic functions of cultured rat liver fat-storing cells and myofibroblasts

1 reference

12 December 2020

Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation

1 reference

12 December 2020

Effects of two methylxanthines, pentoxifylline and propentofylline, on arachidonic acid metabolism in platelets stimulated by thrombin

1 reference

12 December 2020

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline

1 reference

12 December 2020

Vitamin E dietary supplementation inhibits transforming growth factor beta 1 gene expression in the rat liver

1 reference

12 December 2020

Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts

1 reference

12 December 2020

An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis

1 reference

12 December 2020

Identifiers

DOI

10.1136/GUT.50.2.241

1 reference

1113179

1113179

1 reference

1 reference

1 reference