The p41 isoform of invariant chain is a chaperone for cathepsin L (Q28345078)

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R A Roberts

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K Valentijn

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C Driessen

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H S Overkleeft

5

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A Erickson

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P J Peters

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E Bikoff

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P Wolf Bryant

Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

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language of work or name

English

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publication date

1 August 2001

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published in

The EMBO Journal

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volume

20

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issue

15

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page(s)

4055-64

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cites work

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Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes

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Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

20 March 2017

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Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L

20 March 2017

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Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading

20 March 2017

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Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation

20 March 2017

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Proteases involved in MHC class II antigen presentation

20 March 2017

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Cathepsin S required for normal MHC class II peptide loading and germinal center development

20 March 2017

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Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

20 March 2017

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MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

20 March 2017

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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

20 March 2017

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Subcellular localization of Rab17 by cryo-immunogold electron microscopy in epithelial cells grown on polycarbonate filters

7 April 2017

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Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages

29 September 2017

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Proteolysis in MHC class II antigen presentation: who's in charge?

29 September 2017

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Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells

29 September 2017

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Abundant empty class II MHC molecules on the surface of immature dendritic cells

29 September 2017

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Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.

29 September 2017

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The lysosomal cysteine proteases

29 September 2017

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Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism

29 September 2017

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The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain

29 September 2017

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How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway

29 September 2017

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Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

29 September 2017

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Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages

29 September 2017

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Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain

29 September 2017

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Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin

29 September 2017

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Biosynthesis of lysosomal endopeptidases

29 September 2017

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Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules

29 September 2017

1 reference

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Multiple processing of procathepsin L to cathepsin L in vivo

29 September 2017

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Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

2 June 2018

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In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain

2 June 2018

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Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells.

2 June 2018

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The pH-dependent membrane association of procathepsin L is mediated by a 9-residue sequence within the propeptide.

2 June 2018

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Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages

2 June 2018

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Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

2 June 2018

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Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

2 June 2018

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Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41.

2 June 2018

1 reference

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pH-induced conformational transitions of the propeptide of human cathepsin L. A role for a molten globule state in zymogen activation

2 June 2018

1 reference

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Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

27 November 2018

1 reference

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Intracellular transport of class II MHC molecules directed by invariant chain.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149174

Differential expression of the invariant chain in mouse tumor cells: relationship to B lymphoid development

27 November 2018

1 reference

12 December 2020

Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney

1 reference

12 December 2020

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1 reference

12 December 2020

Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain

1 reference

12 December 2020

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

1 reference

12 December 2020

Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice

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Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties

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Procathepsins L and D are membrane-bound in acidic microsomal vesicles

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12 December 2020