Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes (Q28345343)

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S Yakar

3

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J Dupont

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C Hernandez-Sanchez

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A L Castle

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J Filmore

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G I Shulman

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D Le Roith

Troglitazone action is independent of adipose tissue

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language of work or name

English

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publication date

1 August 2001

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published in

Genes & Development

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volume

15

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page(s)

1926-34

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issue

15

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cites work

1 reference

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Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)

20 March 2017

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Molecular and cellular aspects of the insulin-like growth factor I receptor

20 March 2017

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Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

20 March 2017

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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

20 March 2017

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Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice

29 September 2017

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Normal growth and development in the absence of hepatic insulin-like growth factor I

29 September 2017

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Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

29 September 2017

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Genetics of non-insulin-dependent (type-II) diabetes mellitus

29 September 2017

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Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality

29 September 2017

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Insulin-like growth factor-1 therapy in diabetes: physiologic basis, clinical benefits, and risks

29 September 2017

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A generic intron increases gene expression in transgenic mice

29 September 2017

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Insulin/IGF-I receptor hybrids: a mechanism for increasing receptor diversity

29 September 2017

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Insulin/IGF‐1 hybrid receptors: Implications for the dominant‐negative phenotype in syndromes of insulin resistance

29 September 2017

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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

29 September 2017

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Different effects of IGF-I on insulin-stimulated glucose uptake in adipose tissue and skeletal muscle

27 November 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

27 November 2018

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Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.

27 November 2018

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Nutritional state regulates insulin receptor and IRS-1 phosphorylation and expression in chicken.

27 November 2018

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Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia.

27 November 2018

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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

27 November 2018

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Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

27 November 2018

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Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

27 November 2018

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12 December 2020

Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice

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12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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12 December 2020

Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle

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12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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12 December 2020

TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

1 reference

12 December 2020

Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice

1 reference

12 December 2020

Expression of kinase-inactive mutant insulin receptors does not rescue insulin receptor-deficient mice from perinatal death

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12 December 2020

Identifiers

DOI

10.1101/GAD.908001

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478290

478290

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1 reference

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