Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. (Q54104864)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. (English)

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

type 2 diabetes

0 references

1 reference

based on heuristic

inferred from title

Catherine Postic

4

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

5

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

6

object named as

Kahn CR

1 reference

Europe PubMed Central

24 May 2018

author name string

Kulkarni RN

1

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

Brüning JC

2

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

Winnay JN

3

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

language of work or name

0 references

publication date

1 February 1999

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

96

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

329-339

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

3

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Indirect evidence for short-loop negative feedback of insulin secretion in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin suppresses its own secretion in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response Study

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Low insulin response: a marker of prediabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Maturity-onset diabetes of the young (MODY).

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The evolution of function and response to arginine challenge and pregnancy of portally and systemically placed islet cell grafts in streptozotocin diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The pathogenesis of NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a Feedback Inhibition of Insulin on Insulin Secretion in the Isolated, Perfused Canine Pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Heterogeneous expression of glucokinase among pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescence-activated cell sorted rat islet cells and studies of the insulin secretory process

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inducible gene targeting in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin deficiency and insulin resistance in type 2 (non-insulin-dependent) diabetes: quantitative contributions of pancreatic and peripheral responses to glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative Electron Microscopic Autoradiography of Insulin, Glucagon, and Somatostatin Binding Sites on Islets

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin responses to nonglucose stimuli in non-insulin-dependent diabetes mellitus during a tolbutamide infusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

An integrated view of beta-cell dysfunction in type-II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Banting lecture 1990. Beta-cells in type II diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal Islet and Adipocyte Function in Young B-cell-deficient Rats with Near-Normoglycemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Subregion- and cell type-restricted gene knockout in mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathogenesis of NIDDM--a disease of deficient insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Pancreatic hormone receptors on islet cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for presence of insulin receptors in rat islets of Langerhans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980546-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0092-8674(00)80546-2

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

release_7rtu5ynvujgdfiqudfugm5rgea

1 reference

https://api.fatcat.wiki/v0/release/7rtu5ynvujgdfiqudfugm5rgea

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/10025399

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q54104864&oldid=1844395801"