Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6 (Q28361814)

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6 November 2019

title

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6 (English)

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6 November 2019

author name string

G P Hayhurst

1

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6 November 2019

J Harlow

2

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6 November 2019

J Chowdry

3

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6 November 2019

E Gross

4

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6 November 2019

E Hilton

5

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6 November 2019

M S Lennard

6

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6 November 2019

G T Tucker

7

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6 November 2019

S W Ellis

8

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6 November 2019

language of work or name

English

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publication date

1 April 2001

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6 November 2019

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6 November 2019

volume

355

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6 November 2019

issue

Pt 2

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6 November 2019

page(s)

373-379

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Protein measurement with the Folin phenol reagent

6 November 2019

cites work

1 reference

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

20 March 2017

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

20 March 2017

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Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

20 March 2017

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Structure of cytochrome P450eryF involved in erythromycin biosynthesis

20 March 2017

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Rapid and efficient site-specific mutagenesis without phenotypic selection

20 March 2017

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

20 March 2017

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Three and four dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2D6 inhibitors

7 April 2017

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Cytochrome P450 substrate specificities, substrate structural templates and enzyme active site geometries

29 September 2017

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Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.

29 September 2017

1 reference

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Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

29 September 2017

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A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

29 September 2017

1 reference

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Clinical implications of genetic polymorphism in drug metabolism

29 September 2017

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27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

29 September 2017

1 reference

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Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.

29 September 2017

1 reference

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Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

2 June 2018

1 reference

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Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450.

2 June 2018

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Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes

2 June 2018

1 reference

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Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

2 June 2018

1 reference

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Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

2 June 2018

1 reference

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Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes

2 June 2018

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Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man.

2 June 2018

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Nomenclature for human CYP2D6 alleles

2 June 2018

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Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

27 November 2018

1 reference

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Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

27 November 2018

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12 December 2020

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

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12 December 2020

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450

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12 December 2020

High-efficiency transformation of yeast by electroporation

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12 December 2020

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

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12 December 2020

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

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12 December 2020

The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions

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12 December 2020

A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108

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12 December 2020

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

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12 December 2020

A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

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12 December 2020

10.1042/0264-6021:3550373

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11284724%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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6 November 2019

PubMed publication ID

11284724

1 reference