Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation (Q28362288)

2

0 references

J T Barbey

3

0 references

C Ohrt

4

0 references

S Mohanty

5

0 references

J C Pezzullo

6

0 references

B G Schuster

British Journal of Clinical Pharmacology

7

0 references

language of work or name

English

0 references

publication date

March 2001

0 references

published in

0 references

volume

51

0 references

issue

3

0 references

page(s)

231-7

0 references

cites work

X-ray crystal structure of the antimalarial agent (-)-halofantrine hydrochloride supports stereospecificity for cardiotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Electrocardiographic changes and halofantrine plasma level during acute falciparum malaria.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

QT interval: a measure of drug action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Provocation of ventricular tachycardia by antimalarial drug halofantrine in congenital long QT syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Pharmacokinetic and pharmacodynamic modeling in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Malaria: treatment efficacy of halofantrine (WR 171,669) in initial field trials in Thailand

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Pharmacokinetics of halofantrine in Thai patients with acute uncomplicated falciparum malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Halofantrine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic potential

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Cardiac effects of standard-dose halofantrine therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Cardiac effect of halofantrine.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (WR 171,669).

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Pharmacokinetics of halofantrine in man: effects of food and dose size

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015022

Pharmacokinetics of halofantrine in healthy Thai volunteers

2 June 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

Pharmacokinetics of an extended-dose halofantrine regimen in patients with malaria and in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

Cardiac effects of antimalarial treatment with halofantrine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

Prolonged accumulation of diazepam in obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2001.00351.X

The measurement of the Q-T interval of the electrocardiogram

21 January 2018

1 reference

12 December 2020

Halofantrine-associated ventricular fibrillation in a young woman with no predisposing QTc prolongation

1 reference

12 December 2020

A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine

1 reference

12 December 2020

The determination of the enantiomers of halofantrine and monodesbutylhalofantrine in plasma and whole blood using sequential achiral/chiral high-performance liquid chromatography

1 reference

12 December 2020

The electrocardiographic effects of cetirizine in normal subjects

1 reference

12 December 2020

Prolonged QT interval with halofantrine

1 reference

12 December 2020

Prolonged QT interval with halofantrine

1 reference

12 December 2020