Reduced antibody response to streptavidin through site-directed mutagenesis (Q28364576)

2

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Y Lin

3

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A Henry

4

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J Sanderson

5

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J M Jackson

6

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S Goshorn

7

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A R Rees

8

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S S Graves

describes a project that uses

9

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language of work or name

English

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publication date

March 2001

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published in

Protein Science

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volume

10

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issue

3

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page(s)

491-503

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site-directed mutagenesis

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Raster3D: photorealistic molecular graphics

inferred from title

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH

20 March 2017

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VMD: visual molecular dynamics

20 March 2017

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

20 March 2017

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Replacing the complementarity-determining regions in a human antibody with those from a mouse

20 March 2017

1 reference

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Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation

20 March 2017

1 reference

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A humanized antibody that binds to the interleukin 2 receptor

20 March 2017

1 reference

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Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer

20 March 2017

1 reference

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Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity

29 September 2017

1 reference

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Molecular modeling and preclinical evaluation of the humanized NR-LU-13 antibody

29 September 2017

1 reference

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Thermodynamic and structural consequences of flexible loop deletion by circular permutation in the streptavidin-biotin system

29 September 2017

1 reference

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Structural studies of the streptavidin binding loop

29 September 2017

1 reference

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Engineering subunit association of multisubunit proteins: a dimeric streptavidin.

29 September 2017

1 reference

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Epitope-specific tolerance induction with an engineered immunoglobulin

29 September 2017

1 reference

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Polyethylene glycol modification of a galactosylated streptavidin clearing agent: effects on immunogenicity and clearance of a biotinylated anti-tumour antibody

29 September 2017

1 reference

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Intersubunit contacts made by tryptophan 120 with biotin are essential for both strong biotin binding and biotin-induced tighter subunit association of streptavidin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Recombinant core streptavidins. A minimum-sized core streptavidin has enhanced structural stability and higher accessibility to biotinylated macromolecules.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

29 September 2017

1 reference

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On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5.

29 September 2017

1 reference

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Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Expression of a cloned streptavidin gene in Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Systemic immunotoxin therapy of cancer: advances and prospects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

The quaternary structure of streptavidin in urea

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

The uses and properties of PEG-linked proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Structural correlates of an anticarcinoma antibody: identification of specificity-determining residues (SDRs) and development of a minimally immunogenic antibody variant by retention of SDRs only

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Monoclonal antibodies as reversible equilibrium carriers of radiopharmaceuticals

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Reduction of immunogenicity by covalent modification of murine and rabbit immunoglobulins with oxidized dextrans of low molecular weight

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Hypothesis for the Control of Clotting Factor VIII Inhibitory Antibodies by Decreasing Potency of Helper T‐Cell‐Recognized Epitopes in Factor VIII

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Recombinant staphylokinase variants with reduced antigenicity due to elimination of B-lymphocyte epitopes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Clinical optimization of pretargeted radioimmunotherapy with antibody-streptavidin conjugate and 90Y-DOTA-biotin.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Humanized antibodies as potential therapeutic drugs.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Dextran modification of a Fab'--beta-lactamase conjugate modulated by variable pretreatment of Fab' with amine-blocking reagents.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Site-specific prodrug activation by antibody-beta-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Reshaping human antibodies: grafting an antilysozyme activity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374127

Protein antigenicity: A thermodynamic approach

27 November 2018

1 reference

12 December 2020

A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties

1 reference

12 December 2020

Cooperative biotin binding by streptavidin. Electrophoretic behavior and subunit association of streptavidin in the presence of 6 M urea

1 reference

12 December 2020

Hydrogen Bonding, Hydrophobic Interactions, and Failure of the Rigid Receptor Hypothesis

1 reference

12 December 2020

Characterization and crystallization of core streptavidin

1 reference

12 December 2020

Elimination of a major inhibitor epitope in factor VIII

1 reference

12 December 2020

Recombinant staphylokinase variants with altered immunoreactivity. IV: Identification of variants with reduced antibody induction but intact potency

1 reference

12 December 2020

Mapping the common antigenic determinants in avidin and streptavidin

1 reference

12 December 2020

Identifiers

DOI

10.1110/PS.19901

1 reference

4727002

4727002

1 reference

1 reference

1 reference